The Registry of Toxic Effects of Chemical Substances

Phenol, o - chloro -

RTECS #: SK2625000

CAS #: 95-57-8

UPDATE: February 2004 MW: 128.56 MF: C6H5ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. o - Chlorophenic acid
  2. o - Chlorophenol
  3. 2 - Chlorophenol
  4. o - Chlorphenol (German)
  1. 2 - Hydroxychlorobenzene
  2. Phenol, 2 - chloro -
  3. RCRA waste number U048


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction hamster lung 800 µmol/L MUREAV 182,135,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,550 mg/kg (70 day prior to copulation/1-21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Stillbirth 		EVHPAZ 46,137,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 4,800 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 3,100 mg/m3/6 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation

Skin and Appendages: Other: Hair 		NTIS** OTS0534816
intraperitoneal
mouse 		lethal dose (50 percent kill): 235 mg/kg N/R JMCMAR 18,868,1975
intraperitoneal
rat 		lethal dose (50 percent kill): 230 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase 		BJPCAL 13,20,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 230 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
intravenous
rabbit 		lowest published lethal dose: 120 mg/kg N/R HBTXAC 5,112,1959
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 440 mg/kg Behavioral: Muscle weakness

Behavioral: Muscle contraction or spasticity

Skin and Appendages: Other: Sweating 		TIVSAI 33,258,1969
oral
mouse 		lethal dose (50 percent kill): 345 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TOLED5 29,39,1985
oral
mouse 		lethal dose (50 percent kill): 345 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		TOLED5 29,39,1985
oral
mouse 		lethal dose (50 percent kill): 345 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
oral
rat 		lethal dose (50 percent kill): 40 mg/kg Lung, Thorax, or Respiration: Pulmonary emboli

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0534844
oral
rat 		lethal dose (50 percent kill): 670 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
subcutaneous
frog 		lowest published lethal dose: 400 mg/kg N/R HBTXAC 5,112,1959
subcutaneous
guinea pig 		lowest published lethal dose: 800 mg/kg N/R HBAMAK 4,1361,1935
subcutaneous
rat 		lethal dose (50 percent kill): 950 mg/kg N/R FEPRA7 2,76,1943
subcutaneous
rat 		lethal dose (50 percent kill): 950 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
subcutaneous
rabbit 		lowest published lethal dose: 950 mg/kg N/R HBAMAK 4,1361,1935
skin
rabbit 		lowest published lethal dose: 1,580 mg/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Liver: Other changes 		NTIS** OTS0534831


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,450 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** PB85-101772


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, Skin, jan1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84363;
Number of Industries 1;
Total Number of Facilities 23;
Number of Occupations 1;
Total Number of Employees Exposed 495
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84363;
Number of Industries 2;
Total Number of Facilities 158;
Number of Occupations 4;
Total Number of Employees Exposed 974;
Total Number of Female Employees Exposed 323


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in production of dyestuffs, pharmaceuticals, resins and preservatives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9019
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TIVSAI Trudy, VNIIVS. Transactions of the All-Union Scientific Research Institute of Veterinary Sanitation. (VNIIVS, Moscow, USSR) V.11- 1957-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as intermediate in production of dyestuffs, pharmaceuticals, resins and preservatives

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

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