The Registry of Toxic Effects of Chemical Substances
Phenol, m - chloro - |
UPDATE: February 2004 | MW: 128.56 | MF: C6H5ClO |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
mutation in microorganisms | Salmonella typhimurium | 10 痢/plate (+/-enzymatic activation step) | TECSDY 14,143,1987 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
skin mouse | lowest published toxic dose: 6,000 mg/kg/15 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors | CNREA8 19,413,1959 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal rat | lethal dose (50 percent kill): 355 mg/kg |
Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Body temperature increase | BJPCAL 13,20,1958 |
intraperitoneal rat | lethal dose (50 percent kill): 355 mg/kg |
Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,245,1994 |
oral mouse | lethal dose (50 percent kill): 521 mg/kg |
Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation | TOLED5 29,39,1985 |
oral mouse | lethal dose (50 percent kill): 521 mg/kg |
Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold | TOLED5 29,39,1985 |
oral rat | lethal dose (50 percent kill): 570 mg/kg | N/R | FEPRA7 2,76,1943 |
oral rat | lethal dose (50 percent kill): 520 mg/kg |
Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,245,1994 |
subcutaneous rat | lethal dose (50 percent kill): 1,390 mg/kg | N/R | FEPRA7 2,76,1943 |
subcutaneous rat | lethal dose (50 percent kill): 1,390 mg/kg |
Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,245,1994 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
N/R | N/R | N/R |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - DENMARK | time-weighted average 0.5 mg/m3, Skin, JAN1999 | |
Occupational Exposure Limit - SWEDEN | time-weighted average 0.5 mg/m3 short term exposure limit 1.5 mg/m3, Skin, JAN1999 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X4138![]() Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 919; Total Number of Female Employees Exposed 306 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY |
REFERENCES: | |
CODEN |
REFERENCE |
BJPCAL | British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. |
CNREA8 | Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- |
FEPRA7 | Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. |
TECSDY | Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981- |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |