The Registry of Toxic Effects of Chemical Substances

Phenol, m - chloro -

RTECS #: SK2450000

CAS #: 108-43-0

UPDATE: February 2004 MW: 128.56 MF: C6H5ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. m - Chlorophenic acid
  2. m - Chlorophenol
  3. 3 - Chlorophenol
  1. 3 - Hydroxychlorobenzene
  2. Phenol, 3 - chloro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 10 µg/plate (+/-enzymatic activation step) TECSDY 14,143,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 6,000 mg/kg/15 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 355 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature increase 		BJPCAL 13,20,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 355 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
oral
mouse 		lethal dose (50 percent kill): 521 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TOLED5 29,39,1985
oral
mouse 		lethal dose (50 percent kill): 521 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		TOLED5 29,39,1985
oral
rat 		lethal dose (50 percent kill): 570 mg/kg N/R FEPRA7 2,76,1943
oral
rat 		lethal dose (50 percent kill): 520 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994
subcutaneous
rat 		lethal dose (50 percent kill): 1,390 mg/kg N/R FEPRA7 2,76,1943
subcutaneous
rat 		lethal dose (50 percent kill): 1,390 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,245,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3 short term exposure limit 1.5 mg/m3, Skin, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4138;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 919;
Total Number of Female Employees Exposed 306


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as intermediate in production of dyestuffs and phenol resins

RTECS Compound Description:
   Tumorigen
   Mutagen

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