The Registry of Toxic Effects of Chemical Substances

Peroxyacetic acid

RTECS #: SD8750000

CAS #: 79-21-0

UPDATE: August 2004 MW: 76.06 MF: C2H4O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acetic peroxide
  2. Acetyl hydroperoxide
  3. Acide peracetique (French)
  4. Osbon AC
  5. Peracetic acid
  6. Peroxoacetic acid
  7. Desoxon 1
  1. Estosteril
  2. Ethaneperoxoic acid
  3. Hydroperoxide, acetyl
  4. Kyselina peroxyoctova (Czech)
  5. Monoperacetic acid
  6. Proxitane 4002


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe UCDS** 12/12/1968
skin
rabbit 		500 mg open irritation test severe UCDS** 12/12/1968


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage multiple
other fish 		0.61 mg/l/20 day- continuous MUREAV 557,119,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 21 gm/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 55,1359,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 450 mg/m3 N/R GISAAA 48(6),28,1983
intravenous
mouse 		lethal dose (50 percent kill): 17,860 µg/kg N/R YHTPAD 23,345,1988
oral
guinea pig 		lethal dose (50 percent kill): 10 mg/kg N/R BSPII* 1/75-19B
oral
mouse 		lethal dose (50 percent kill): 210 mg/kg N/R GISAAA 48(6),28,1983
oral
rat 		lethal dose (50 percent kill): 1,540 µL/kg N/R UCDS** 12/12/1968
skin
rabbit 		lethal dose (50 percent kill): 1,410 µL/kg N/R UCDS** 12/12/1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 186 mg/m3/1 hour/90 day- intermittent Liver: Fatty liver degeneration

Lung, Thorax, or Respiration: Other changes

Blood: Pigmented or nucleated red blood cells 		WZHMAE 33,513,1984
inhalation
mouse 		lowest published toxic concentration: 186 mg/m3/1 hour/90 day- intermittent Liver: Fatty liver degeneration

Lung, Thorax, or Respiration: Other changes 		WZHMAE 33,513,1984
inhalation
rat 		lowest published toxic concentration: 350 mg/m3/30 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		GISAAA 48(6),28,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,331,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84020;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 2;
Total Number of Employees Exposed 1,683
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84020;
Number of Industries 2;
Total Number of Facilities 31;
Number of Occupations 4;
Total Number of Employees Exposed 1,728;
Total Number of Female Employees Exposed 91


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BSPII* SPI Bulletin. (Soc. of the Plastics Industry, 250 Park Ave., New York, NY 10017)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
WZHMAE Wissenschaftliche Zeitschrift der Humboldt-Universitaet zu Berlin, Mathematisch- Naturwissenschaftliche Reihe. (DDR-1004 Berlin, Strasse der Pariser Kommune 3/4, zu richten) V.1-36, 1951/52-87.
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PERACETIC ACID), PRAB, 6/80

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Primary Irritant

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