The Registry of Toxic Effects of Chemical Substances

Permanganic acid, potassium salt

RTECS #: SD6475000

CAS #: 7722-64-7

UPDATE: May 2004 MW: 158.04 MF: MnO4•K


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Chameleon mineral
  2. C.I. 77755
  3. Condy's crystals
  4. Cairox
  5. Permanganate de potassium (French)
  1. Permanganate of potash
  2. Potassio (permanganato di) (Italian)
  3. Potassium permanganate
  4. Potassium (permanganate de) (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		718 mg/kg/7 day- continuous MUREAV 240,159,1990
cytogenetic analysis mouse mammary gland 1 mmol/L/48 hour MUREAV 67,221,1979
DNA adduct Escherichia coli 200 µmol/L MUREAV 89,95,1981
DNA repair Bacillus subtilis 17 mg/L WATRAG 14,1613,1980
DNA repair Escherichia coli 625 µg/well MUREAV 133,161,1984
mutation in microorganisms other microorganisms 10 ppm (-enzymatic activation step) JOBAAY 54,767,1947
mutation in microorganisms Salmonella typhimurium 10 µL/tube (+enzymatic activation step) MUREAV 260,295,1991
micronucleus test oral
mouse 		205 mg/kg/24 hour- continuous MUREAV 240,159,1990
phage inhibition capacity Escherichia coli 200 µmol/L ENMUDM 6,59,1984
sperm morphology oral
mouse 		513 mg/kg/5 day- continuous MUREAV 240,159,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
gerbil 		lowest published toxic dose: 25 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) IJEBA6 14,617,1976
intratesticular
rat 		lowest published toxic dose: 400 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) FESTAS 24,884,1973
oral
mouse 		lowest published toxic dose: 513 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 240,159,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rabbit 		lowest published lethal dose: 70 mg/kg N/R EQSSDX 1,1,1975
oral
dog 		lowest published lethal dose: 400 mg/kg N/R YKYUA6 31,855,1980
oral
guinea pig 		lethal dose (50 percent kill): 1,151 mg/kg Behavioral: Somnolence (general depressed activity) GISAAA 36(9),15,1971
oral
human 		lowest published lethal dose: 143 mg/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes 		34ZIAG -,493,1969
oral
human 		lowest published lethal dose: 71 mg/kg N/R VCVN5* -,411,1989
oral
mouse 		lethal dose (50 percent kill): 2,157 mg/kg Behavioral: Somnolence (general depressed activity) GISAAA 36(9),15,1971
oral
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R VCVN5* -,410,1989
oral
rat 		lethal dose (50 percent kill): 750 mg/kg N/R VCVN5* -,410,1989
oral
rabbit 		lowest published lethal dose: 600 mg/kg N/R YKYUA6 31,855,1980
oral
woman 		lowest published toxic dose: 2,400 µg/kg/ day Gastrointestinal: Nausea or vomiting AIPTAK 44,446,1933
oral
woman 		lowest published lethal dose: 100 mg/kg Vascular: BP lowering not characterized in autonomic section

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		HETOEA 15,259,1996


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7,851 mg/kg/39 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 36(9),15,1971
oral
rat 		lowest published toxic dose: 910 mg/kg/91 day- intermittent Behavioral: Alteration of classical conditioning VCVN5* -,411,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
CREOH* 42,25,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 5 mg(Mn)/m3 DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.3 mg(Mn)/m3, short term exposure limit 0.6 mg(Mn)/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m3, respirable dust, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, MAC( continuous) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 mg(Mn)/m3, KTV 2.5 mg(Mn)/m3 (resp. dust), JAN1999
Occupational Exposure Limit - SWEDEN NGV 2.5 mg(Mn)/m3, KTV 5 mg(Mn)/m3 (total dust), JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 5 mg(Mn)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 60490;
Number of Industries 47;
Total Number of Facilities 2,685;
Number of Occupations 38;
Total Number of Employees Exposed 26,428
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 60490;
Number of Industries 52;
Total Number of Facilities 3,004;
Number of Occupations 64;
Total Number of Employees Exposed 91,985;
Total Number of Female Employees Exposed 28,113


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; N crassa-reversion
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
WATRAG Water Research. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1967-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a topical antibacterial agent

NIOSH PROFILE (MANGANESE AND ITS COMPOUNDS), SRC, 4/82

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

 Click Here for Additional Information about RTECS