The Registry of Toxic Effects of Chemical Substances

2,4 - Pentanediol, 2 - methyl -

RTECS #: SA0810000

CAS #: 107-41-5

UPDATE: November 2004 MW: 118.20 MF: C6H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,4 - Dihydroxy - 2 - methylpentane
  2. 2 - Methyl pentane - 2,4 - diol
  3. 2 - Methyl - 2,4 - pentanediol
  4. Diolane
  5. Hexylene glycol
  1. Hexylene glycol (ACGIH)
  2. Isol
  3. Pinakon
  4. alpha,alpha,alpha' - Trimethyltrimethylene glycol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		93 mg severe BIOFX* 12-4/1970
skin
rabbit 		465 mg open irritation test mild UCDS** 11/3/1971
skin
rabbit 		465 mg/24 hour moderate JPETAB 82,377,1944
skin
rabbit 		500 mg/24 hour moderate FCTXAV 16,777,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 50 ppm/15 minute Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes 		34ZIAG -,312,1969
inhalation
human 		lowest published toxic concentration: 50 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		JIHTAB 28,262,1946
inhalation
rat 		lethal concentration (50 percent kill): >310 mg/m3/1 hour N/R BIOFX* 12-4/1970
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,299 mg/kg N/R SCCUR* -,5,1961
intraperitoneal
rat 		lowest published lethal dose: 1,500 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Renal function tests depressed 		JPPMAB 11,150,1959
oral
guinea pig 		lethal dose (50 percent kill): 2,800 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes 		FEPRA7 4,142,1945
oral
mouse 		lethal dose (50 percent kill): 3,097 mg/kg N/R JAPMA8 45,669,1956
oral
rat 		lethal dose (50 percent kill): 3,700 mg/kg N/R NPIRI* 1,68,1974
oral
rabbit 		lethal dose (50 percent kill): 3,200 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes 		FEPRA7 4,142,1945
subcutaneous
rabbit 		lethal dose (50 percent kill): 13 gm/kg Skin: After systemic exposure: Dermatitis, other FCTXAV 16,777,1978
skin
rabbit 		lethal dose (50 percent kill): 8,560 µL/kg N/R 34ZIAG -,731,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 33,600 mg/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight 		BIOFX* 12-4/1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 25 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
JACTDZ 4(5),223,1985


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,256,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (125 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM short term exposure limit 25 ppm (121 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (125 mg/m3), short term exposure limit 40 ppm (190 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VLE 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 125 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 25 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEXYLENE GLYCOL-air ceiling concentration 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 37630;
Number of Industries 224;
Total Number of Facilities 30,332;
Number of Occupations 149;
Total Number of Employees Exposed 373,068
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 37630;
Number of Industries 253;
Total Number of Facilities 43,088;
Number of Occupations 167;
Total Number of Employees Exposed 754,186;
Total Number of Female Employees Exposed 231,390


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in brake fluids, inks and lubricants and as an intermediate and fuel additive
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in brake fluids, inks and lubricants and as an intermediate and fuel additive

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (HEXYLENE GLYCOL), SRC, 10/81

RTECS Compound Description:
   Human Data
   Primary Irritant

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