The Registry of Toxic Effects of Chemical Substances

3 - Pentanone

RTECS #: SA8050000

CAS #: 96-22-0

UPDATE: November 2004 MW: 86.15 MF: C5H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. DEK
  2. Diethyl ketone
  3. Diethyl ketone (ACGIH)
  4. Diethylcetone (French)
  5. Dimethylacetone
  1. Metacetone
  2. Methacetone
  3. Pentanone - 3
  4. Propione


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg moderate UCDS** 4/25/1958
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,282,1986
skin
rabbit 		410 mg open irritation test mild UCDS** 4/25/1958
skin
rabbit 		500 mg/24 hour mild 85JCAE -,282,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 14,800 ppm MUREAV 149,339,1985
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 14,800 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 10,61,1954
intraperitoneal
rat 		lowest published lethal dose: 1,250 mg/kg N/R JIHTAB 27,1,1945
intravenous
mouse 		lethal dose (50 percent kill): 513 mg/kg N/R JPMSAE 67,566,1978
oral
mouse 		lethal dose (50 percent kill): 3,100 mg/kg Behavioral: General anesthetic

Behavioral: Ataxia 		MTPEEI (4),41,1997
oral
mouse 		lethal dose (50 percent kill): 3,200 mg/kg N/R VCVGK* -,422,1994
oral
rat 		lethal dose (50 percent kill): 2,140 mg/kg N/R UCDS** 4/25/1958
skin
rat 		lethal dose (50 percent kill): 2,100 mg/kg N/R VCVGK* -,422,1994
skin
rabbit 		lethal dose (50 percent kill): 20 mL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm; short term exposure limit 300 ppm DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 300 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (705 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (705 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (705 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (350 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (705 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (716 mg/m3), short term exposure limit 250 ppm, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 705 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 300 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 300 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYL KETONE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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