The Registry of Toxic Effects of Chemical Substances

2 - Pentanone

RTECS #: SA7875000

CAS #: 107-87-9

UPDATE: November 2004 MW: 86.15 MF: C5H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Pentanone (OSHA)
  2. Ethyl acetone
  3. MPK
  4. Methyl propyl ketone
  5. Methyl propyl ketone (ACGIH:OSHA)
  1. Methyl - n - propyl ketone
  2. Methyl - propyl - cetone (French)
  3. Methylpropyl ketone
  4. Metylopropyloketon (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		405 mg open irritation test mild UCDS** 7/20/1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 13,600 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 50,000 mg/m3 Gastrointestinal: Changes in structure or function of salivary glands VCVGK* -,421,1994
inhalation
guinea pig 		lowest published lethal concentration: 13,000 ppm/5 hour N/R 85INA8 6,1036,1991
inhalation
guinea pig 		lowest published lethal concentration: 105,000 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,421,1994
inhalation
human 		lowest published toxic concentration: 1,500 ppm Eye: Other eye effects

Behavioral: Headache

Gastrointestinal: Nausea or vomiting 		NPIRI* 1,83,1974
inhalation
human 		lowest published toxic concentration: 3,000 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,421,1994
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 22 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse 		lowest published toxic concentration: 15,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,421,1994
inhalation
mouse 		lethal concentration (50 percent kill): 22,000 mg/m3/2 hour N/R VCVGK* -,421,1994
inhalation
rat 		lowest published lethal concentration: 2,000 ppm/4 hour N/R AIHAAP 23,95,1962
inhalation
rabbit 		lowest published toxic concentration: 1,250 mg/m3 Brain and Coverings: Other degenerative changes VCVGK* -,421,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,600 mg/kg N/R 38MKAJ 2C,4735,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4735,1982
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 3,700 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse 		lethal dose (50 percent kill): 1,600 mg/kg N/R 38MKAJ 2C,4735,1982
oral
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R 38MKAJ 2C,4735,1982
skin
rabbit 		lethal dose (50 percent kill): 6,500 mg/kg N/R NPIRI* 1,83,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm;short term exposure limit 250 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 250 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (700 mg/m3) DTLVS* 3,200,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (700 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (700 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (700 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (700 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (700 mg/m3), short term exposure limit 250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (705 mg/m3), short term exposure limit 250 ppm (881 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (700 mg/m3), short term exposure limit 250 ppm (875 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 200 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 700 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (700 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 800 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (700 mg/m3), KZG- week 400 ppm (1400 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (700 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (716 mg/m3), short term exposure limit 250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 250 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 250 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL PROPYL KETONE-air 10 hour time-weighted average 150 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54480;
Number of Industries 4;
Total Number of Facilities 39;
Number of Occupations 11;
Total Number of Employees Exposed 789
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54480;
Number of Industries 17;
Total Number of Facilities 930;
Number of Occupations 13;
Total Number of Employees Exposed 8,218;
Total Number of Female Employees Exposed 1,129


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, as a flavoring agent, and in organic synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent, as a flavoring agent, and in organic synthesis

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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