The Registry of Toxic Effects of Chemical Substances

2 - Pentanol, 4 - methyl -

RTECS #: SA7350000

CAS #: 108-11-2

UPDATE: November 2004 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 4 - pentanol
  2. 3 - Mic
  3. 4 - Methyl - 2 - pentanol
  4. 4 - Methylpentanol - 2
  5. 4 - Metilpentan - 2 - olo (Italian)
  6. 4 - Pentanol, 2 - methyl -
  7. Alcool methyl amylique (French)
  8. Isobutylmethylcarbinol
  9. Isobutylmethylmethanol
  1. MAOH
  2. MIBC
  3. MIC
  4. Methyl amyl alcohol (OSHA)
  5. Methyl isobutyl carbinol
  6. Methyl isobutyl carbinol (ACGIH:OSHA)
  7. Methyl - isobutylkarbinol (Czech)
  8. Methylisobutyl carbinol
  9. Metilamil alcohol (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 4.32 mg/m3 Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		GISAAA 5,8,1994
inhalation
rat 		lowest published lethal concentration: 2,000 ppm/4 hour N/R JIHTAB 31,343,1949
intraperitoneal
mouse 		lethal dose (50 percent kill): 812 mg/kg N/R SCCUR* -,7,1961
oral
mouse 		lowest published lethal dose: 1 gm/kg Gastrointestinal: Other changes UCPHAQ 2,217,1949
oral
rat 		lethal dose (50 percent kill): 2,590 mg/kg N/R AMIHBC 4,119,1951
oral
rat 		lowest published toxic dose: 510 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 136,199,2003
skin
rabbit 		lethal dose (50 percent kill): 3,560 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm (skin);short term exposure limit 40 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 40 ppm (skin) DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (100 mg/m3) DTLVS* 3,166,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (100 mg/m3), short term exposure limit 40 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (104 mg/m3), short term exposure limit 40 ppm, Skin JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (100 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (100 mg/m3), short term exposure limit 40 ppm (170 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (100 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 25 ppm (100 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 160 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 25 ppm (100 mg/m3), short term exposure limit 125 ppm, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (100 mg/m3), KZG- week 125 ppm (500 mg/m3),Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (106 mg/m3), short term exposure limit 40 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 40 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 40 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 25 ppm (Sk);
short term exposure limit 40 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3241;
Number of Industries 31;
Total Number of Facilities 2,585;
Number of Occupations 33;
Total Number of Employees Exposed 26,405;
Total Number of Female Employees Exposed 2,882


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
UCPHAQ University of California, Berkeley, Publications in Pharmacology. (Berkeley, CA) V.1-3, 1938-57. Discontinued.

Used as a solvent

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