The Registry of Toxic Effects of Chemical Substances

2,4 - Pentanedione

RTECS #: SA1925000

CAS #: 123-54-6

UPDATE: November 2003 MW: 100.13 MF: C5H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acetoacetone
  2. Acetone, acetyl -
  3. Acetyl 2 - propanone
  4. Acetyl - 2 - propaneone
  5. Acetylaceetone
  1. Acetylacetone
  2. Diacetylmethane
  3. Pentanedione
  4. Pentanedione - 2,4


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg severe AJOPAA 29,1363,1946
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit 		488 mg open irritation test mild UCDS** 7/8/1971
skin
rabbit 		11.2 mL/6 hour- intermittent mild VHTODE 43,14,2001
skin
rabbit 		33.6 mL/6 hour- intermittent moderate VHTODE 43,14,2001
skin
rabbit 		11.2 mL/2 day- intermittent moderate VHTODE 43,14,2001


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test inhalation
rat 		694 ppm/6h/5 day TIHEEC 5,463,1989
mutation in mammalian somatic cells hamster ovary 80 mg/L EPASR* 8EHQ-0386-0595


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 398 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TIHEEC 6,461,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 1,000 ppm/4 hour N/R JIHTAB 31,343,1949
intraperitoneal
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat 		lowest published lethal dose: 400 mg/kg N/R BCPCA6 13,285,1964
oral
mouse 		lethal dose (50 percent kill): 951 mg/kg N/R 38MKAJ 2C,4773,1982
oral
rat 		lethal dose (50 percent kill): 55 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Rigidity (includes catalepsy) 		GISAAA 52(10),88,1987
oral
rat 		lethal dose (50 percent kill): 55 mg/kg Behavioral: General anesthetic

Behavioral: Tetany 		VCVGK* -,448,1994
skin
guinea pig 		lowest published lethal dose: 20 mL/kg N/R NTIS** OTS0533573
skin
rabbit 		lethal dose (50 percent kill): 810 µL/kg N/R DCTODJ 9,133,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 805 ppm/6 hour/9 day- intermittent Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 7,329,1986
inhalation
rat 		lowest published toxic concentration: 650 ppm/6 hour/14 week- intermittent Brain and Coverings: Other degenerative changes

Brain and Coverings: Changes in brain weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FAATDF 7,329,1986
oral
rat 		lowest published toxic dose: 10 gm/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0533731
oral
rabbit 		lowest published toxic dose: 6 gm/kg/12 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0533573
skin
rabbit 		lowest published toxic dose: 3,900 mg/kg/4 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0557686
skin
rabbit 		lowest published toxic dose: 8,775 mg/kg/11 day- intermittent Brain and Coverings: Other degenerative changes

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0510542-3
skin
rabbit 		lowest published toxic dose: 2,925 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VHTODE 43,14,2001
skin
rabbit 		lowest published toxic dose: 2,926 mg/kg/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VHTODE 43,14,2001
skin
rabbit 		lowest published toxic dose: 7,315 mg/kg/5 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VHTODE 43,14,2001
skin
rabbit 		lowest published toxic dose: 1,950 mg/kg/2 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake 		VHTODE 43,14,2001
skin
rabbit 		lowest published toxic dose: 5,852 mg/kg/4 day- intermittent Brain and Coverings: Changes in circulation

Endocrine: Other changes

Blood: Changes in spleen 		VHTODE 43,14,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOPADD 21,165,2001


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84754;
Number of Industries 3;
Total Number of Facilities 221;
Number of Occupations 3;
Total Number of Employees Exposed 3,030
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84754;
Number of Industries 9;
Total Number of Facilities 350;
Number of Occupations 23;
Total Number of Employees Exposed 6,171;
Total Number of Female Employees Exposed 1,577


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for making gasoline and lubricant additives, fungicides, insecticides and colors
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used for making gasoline and lubricant additives, fungicides, insecticides and colors

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Primary Irritant

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