The Registry of Toxic Effects of Chemical Substances

Pentane

RTECS #: RZ9450000

CAS #: 109-66-0

UPDATE: November 2004 MW: 72.17 MF: C5H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Amyl hydride
  2. Pentanen (Dutch)
  3. Pentan (Polish)
  1. Skellysolve A
  2. Pentane (ACGIH:OSHA)
  3. Pentani (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 130 mg/m3 Brain and Coverings: Changes in surface EEG

Behavioral: Somnolence (general depressed activity)

Behavioral: Headache 		VCVGH* -,28,1990
inhalation
mouse 		lowest published lethal concentration: 325 gm/m3/2 hour Behavioral: Excitement JPETAB 58,74,1936
inhalation
mouse 		lowest published toxic concentration: 265,000 mg/m3/5 minute Behavioral: General anesthetic VCVGH* -,28,1990
inhalation
rat 		lethal concentration (50 percent kill): 364 gm/m3/4 hour N/R GTPZAB 32(10),23,1988
intravenous
mouse 		lethal dose (50 percent kill): 446 mg/kg N/R JPMSAE 67,566,1978
oral
rat 		lethal dose (50 percent kill): >2,000 mg/kg N/R JTEHF8 58,35,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 116 mg/m3/117 day- continuous Brain and Coverings: Other degenerative changes

Vascular: BP lowering not characterized in autonomic section 		VCVGH* -,28,1990
inhalation
rat 		lowest published toxic concentration: 8,800 mg/m3/12 hour/16 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVGH* -,28,1990
oral
rat 		lowest published toxic dose: 10 gm/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TIHEEC 1(3),67,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 600 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (1475 mg/m3) DTLVS* 3,200,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (2950 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (1500 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (1500 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (2950 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 600 ppm (1800 mg/m3), short term exposure limit 750 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 600 ppm (1899 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 600 ppm (1770 mg/m3), short term exposure limit 750 ppm (2210 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (1500 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (1500 mg/m3), short term exposure limit 625 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 600 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (2950 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 500 mg/m3, short term exposure limit 1500 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1800 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (2950 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1800 mg/m3, MAC(short term exposure limit) 2300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 300 ppm, short term exposure limit 300 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 600 ppm (1800 mg/m3), KTV 750 ppm (2000 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 600 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (2950 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 600 ppm (1800 mg/m3), short term exposure limit 750 ppm, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 600 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 600 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTANE-air 10 hour time-weighted average 120 ppm;
ceiling concentration 610 ppm/15 minute 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54243;
Number of Industries 31;
Total Number of Facilities 3,762;
Number of Occupations 22;
Total Number of Employees Exposed 34,548
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54243;
Number of Industries 24;
Total Number of Facilities 1,935;
Number of Occupations 47;
Total Number of Employees Exposed 38,465;
Total Number of Female Employees Exposed 10,889


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of ice, low-temperature thermometers and as a blowing agent for plastics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in manufacture of ice, low-temperature thermometers and as a blowing agent for plastics

RTECS Compound Description:
   Drug
   Human Data

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