The Registry of Toxic Effects of Chemical Substances

Pentaerythritol

RTECS #: RZ2490000

CAS #: 115-77-5

UPDATE: November 2004 MW: 136.17 MF: C5H12O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Auxinutril
  2. 2,2 - Bis (hydroxymethyl) - 1,3 - propanediol
  3. Hercules P6
  4. Maxinutril
  5. Methane tetramethylol
  6. Monopentek
  7. PE
  1. Pentaerythrite
  2. Pentek
  3. 1,3 - Propanediol, 2,2 - bis (hydroxymethyl) -
  4. Pentaerythritol (ACGIH:OSHA)
  5. Tetrahydroxymethylmetane
  6. Tetrakis (hydroxymethyl) methane
  7. Tetramethylolmethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >11 gm/m3/6 hour N/R TXAPA9 6,351,1964
oral
guinea pig 		lethal dose (50 percent kill): 11,300 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Ataxia 		TXAPA9 6,351,1964
oral
mouse 		lethal dose (50 percent kill): 25,500 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Ataxia 		TXAPA9 6,351,1964
oral
mouse 		lethal dose (50 percent kill): 18,500 mg/kg N/R VCVGK* -,158,1984
oral
rat 		lethal dose (50 percent kill): 19,500 mg/kg Behavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes 		GISAAA 36(2),25,1971
oral
rat 		lethal dose (50 percent kill): 18,500 mg/kg N/R VCVGK* -,158,1984
oral
rabbit 		lethal dose (50 percent kill): 18,500 mg/kg Behavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes 		GISAAA 36(2),25,1971
oral
rabbit 		lethal dose (50 percent kill): 18,500 mg/kg N/R VCVGK* -,158,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10,600 µg/kg/30 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 36(2),25,1971
oral
rabbit 		lowest published toxic dose: 10,605 mg/kg/30 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin) 		GISAAA 36(2),25,1971


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD NUISANCE PARTICULATES DTLVS* 3,199,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3,JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, total inhalable dust, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 4 mg/m3, respirable dust, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3 (total dust), 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3 (respirable dust), 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, resp. fraction-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTAERYTHRITOL, total dust-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54185;
Number of Industries 93;
Total Number of Facilities 6,400;
Number of Occupations 81;
Total Number of Employees Exposed 89,325
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6984;
Number of Industries 1;
Total Number of Facilities 18;
Number of Occupations 2;
Total Number of Employees Exposed 201
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54185;
Number of Industries 122;
Total Number of Facilities 15,717;
Number of Occupations 97;
Total Number of Employees Exposed 271,094;
Total Number of Female Employees Exposed 60,232


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in coatings and stabilizers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in coatings and stabilizers

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