The Registry of Toxic Effects of Chemical Substances

Pentaborane (9)

RTECS #: RY8925000

CAS #: 19624-22-7

UPDATE: November 2004 MW: 63.14 MF: B5H9


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Nonahydropentaborane
  2. Pentaborane
  1. Pentaborane (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration (50 percent kill): 92 mg/m3/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		JPETAB 145,382,1964
inhalation
monkey 		lethal concentration (50 percent kill): 640 mg/m3/2 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		JPETAB 145,382,1964
inhalation
mouse 		lethal concentration (50 percent kill): 3,400 ppb/4 hour N/R AIHAAP 19,46,1958
inhalation
rat 		lethal concentration (50 percent kill): 6 ppm/4 hour N/R AIHAAP 19,46,1958
inhalation
rat 		lethal concentration (50 percent kill): 18 mg/m3/4 hour N/R VCVN1* -,199,1988
inhalation
rat 		lowest published toxic concentration: 18 mg/m3/30 minute Brain and Coverings: Other degenerative changes VCVN1* -,199,1988
intraperitoneal
dog 		lowest published lethal dose: 15,800 µg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Behavioral: Coma 		STGNBT -,191,1999
intraperitoneal
rat 		lethal dose (50 percent kill): 11,100 µg/kg N/R 14KTAK -,693,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 3,700 ppb/1 hour/3 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 6,121,1964
inhalation
dog 		lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
hamster 		lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
mouse 		lowest published toxic concentration: 3,700 ppb/1 hour/4 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 6,121,1964
inhalation
rat 		lowest published toxic concentration: 67 mg/m3/5 minute/5 day- intermittent Behavioral: Tetany

Eye: Miosis (pupilliary constriction)

Eye: Conjunctiva irritation 		VCVN1* -,199,1988
inhalation
rat 		lowest published toxic concentration: 30 mg/m3/5 day- intermittent Behavioral: Tetany

Eye: Miosis (pupilliary constriction)

Eye: Conjunctiva irritation 		VCVN1* -,199,1988
inhalation
rat 		lowest published toxic concentration: 7.8 mg/m3/60 minute/5 day- intermittent Behavioral: Tetany

Eye: Miosis (pupilliary constriction)

Eye: Conjunctiva irritation 		VCVN1* -,199,1988
inhalation
rat 		lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
rabbit 		lowest published toxic concentration: 2.6 mg/m3/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm;short term exposure limit 0.015 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.015 ppm DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.005 ppm (0.01 mg/m3) DTLVS* 3,197,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.005 ppm (0.01 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.005 ppm, short term exposure limit 0.015 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.005 ppm (0.01 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.01 mg/m3), short term exposure limit 0.013 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.01 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.005 ppm (0.01 mg/m3), short term exposure limit 0.015 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 0.005 ppm (0.01 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.005 ppm (0.01 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.01 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.005 ppm (0.01 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.01 mg/m3), KZG- week 0.01 ppm (0.02 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.01 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 0.015 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 0.015 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTABORANE-air 10 hour time-weighted average 0.005 ppm;
short term exposure limit 0.015 ppm 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

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