The Registry of Toxic Effects of Chemical Substances

Palmitic acid

RTECS #: RT4550000

CAS #: 57-10-3

UPDATE: October 1997 MW: 256.48 MF: C16H32O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cetylic acid
  2. Emersol 140
  3. Emersol 143
  4. Hexadecanoic acid
  5. n - Hexadecanoic acid
  6. n - Hexadecoic acid
  1. Hexadecylic acid
  2. Hydrofol
  3. Hystrene 8016
  4. Hystrene 9016
  5. Industrene 4516
  6. 1 - Pentadecanecarboxylic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		75 mg/3 day- intermittent mild 85DKA8 -,127,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 1,000 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		CNREA8 26,105,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 57 mg/kg Behavioral: Convulsions or effect on seizure threshold APTOA6 18,141,1961
oral
rat 		lethal dose (50 percent kill): >10 gm/kg N/R AIHAAP 37,251,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AMIHAB 21,100,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81460;
Number of Industries 23;
Total Number of Facilities 1,477;
Number of Occupations 34;
Total Number of Employees Exposed 20,670
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81460;
Number of Industries 55;
Total Number of Facilities 5,543;
Number of Occupations 61;
Total Number of Employees Exposed 105,420;
Total Number of Female Employees Exposed 20,470


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in film coatings, ISOPROPYL PALMITATE, skin creams and lotions, esters, deodorants
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-

Used in film coatings, ISOPROPYL PALMITATE, skin creams and lotions, esters, deodorants

RTECS Compound Description:
   Tumorigen
   Natural Product
   Primary Irritant

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