The Registry of Toxic Effects of Chemical Substances

Oxygen

RTECS #: RS2060000

CAS #: 7782-44-7

UPDATE: May 2005 MW: 32.00 MF: O2


NOTE:

TABLE OF CONTENTS:
  1. MUTATION DATA:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

N/R N/R


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis chicken embryo 80 pph ACATA5 94,520,1976
cytogenetic analysis hamster ovary 20 pph/3 day- continuous MUREAV 219,17,1989
cytogenetic analysis hamster lung 80 pph MUREAV 57,27,1978
cytogenetic analysis human lymphocyte 40 pph/4 day HUGEDQ 74,438,1986
mutation in mammalian somatic cells hamster lung 95 pph/24 hour MUREAV 57,27,1978
sister chromatid exchange hamster ovary 20 pph MUREAV 219,17,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 10 pph/24 hour (8 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages NDKIA2 36,89,1985
inhalation
rat 		lowest published toxic concentration: 10 pph/12 hour (22 day pregnant) Reproductive: Specific developmental abnormalities: Respiratory system AJPHAP 257,L221,1989
inhalation
rat 		lowest published toxic concentration: 10 pph/9 hour (22 day pregnant) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Physical 		AJPHAP 257,L221,1989
inhalation
woman 		lowest published toxic concentration: 12 pph/10 minute (26-39 week pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system AJOGAH 82,1055,1961


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 90 pph Lung, Thorax, or Respiration: Other changes

Cardiac: Other changes

Blood: Normocytic anemia 		VCVN5* -,156,1993
inhalation
guinea pig 		lowest published lethal concentration: 80 pph N/R VCVN5* -,156,1993
inhalation
human 		lowest published toxic concentration: 100 pph/14 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes 		JAMAAP 128,710,1945
inhalation
human 		lowest published toxic concentration: 70 pph/55 hour Lung, Thorax, or Respiration: Other changes VCVN5* -,156,1993
inhalation
human 		lowest published toxic concentration: 90 pph/24 hour Peripheral Nerve and Sensation: Paresthesia VCVN5* -,156,1993
inhalation
human 		lowest published toxic concentration: 90 pph/60 hour Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Nausea or vomiting 		VCVN5* -,156,1993
inhalation
human 		lowest published toxic concentration: 100 pph/15 minute Gastrointestinal: Nausea or vomiting VCVN5* -,156,1993
inhalation
human 		lowest published toxic concentration: 100 pph/6 hour Lung, Thorax, or Respiration: Other changes VCVN5* -,156,1993
inhalation
human 		lowest published toxic concentration: 30 pph Vascular: Regional or general arteriolar constriction VCVN5* -,159,1993
inhalation
monkey 		lowest published lethal concentration: 80 pph Lung, Thorax, or Respiration: Acute pulmonary edema

Behavioral: Aggression

Gastrointestinal: Nausea or vomiting 		VCVN5* -,156,1993
inhalation
mouse 		lowest published lethal concentration: 100 pph/24 hour Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease 		VCVN5* -,156,1993
inhalation
rat 		lowest published toxic concentration: 80 pph Lung, Thorax, or Respiration: Other changes VCVN5* -,156,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 90 pph/8 hour/90 day- intermittent Liver: Other changes VCVN5* -,159,1989
inhalation
guinea pig 		lowest published toxic concentration: 100 pph/30 minute/3 day- intermittent Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other 		AANEAB 45,119,2001
inhalation
mouse 		lowest published toxic concentration: 95 pph/2 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 72,10,2003
inhalation
mouse 		lowest published toxic concentration: 95 pph/3 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 72,10,2003
inhalation
mouse 		lowest published toxic concentration: 95 pph/4 day- continuous Lung, Thorax, or Respiration: Changes in lung weight TOXID9 72,11,2003
inhalation
mouse 		lowest published toxic concentration: 95 pph/3 day- continuous Lung, Thorax, or Respiration: Changes in lung weight TOXID9 72,11,2003
inhalation
rat 		lowest published toxic concentration: 100 pph/24 hour/3 day- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** PB225-527
inhalation
rat 		lowest published toxic concentration: 95 pph/24 hour/2 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		ARTODN 73,540,2000
inhalation
rat 		lowest published toxic concentration: 70 pph/24 hour/20 day- continuous Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN5* -,159,1989
inhalation
rat 		lowest published toxic concentration: 85 pph/24 hour/5 day- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		VCVN5* -,159,1989
inhalation
rat 		lowest published toxic concentration: 95 pph/8 day- continuous Lung, Thorax, or Respiration: Other changes JPETAB 299,90,2001
inhalation
rat 		lowest published toxic concentration: 95 pph/7 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		TOXID9 72,110,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
FEPRA7 35,89,1976
TOXICOLOGY REVIEW
CEFYAD 23,513,1974
TOXICOLOGY REVIEW
PTPBD7 1,731,1975
TOXICOLOGY REVIEW
32RWA4 1,239,1976
TOXICOLOGY REVIEW
ANESAV 37,210,1972
TOXICOLOGY REVIEW
TXAPA9 181,60,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0006;
Number of Industries 23;
Total Number of Facilities 917;
Number of Occupations 33;
Total Number of Employees Exposed 9,677
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0006;
Number of Industries 81;
Total Number of Facilities 7,113;
Number of Occupations 90;
Total Number of Employees Exposed 189,129;
Total Number of Female Employees Exposed 87,473


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in various oxidation processes, for feedstock and enrichment purposes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Oxygen, 6601


REFERENCES:

CODEN
REFERENCE
32RWA4 "Free Radicals in Biology," Pryor, W.A., ed., V.1- , New York, Academic Press, Inc., 1976-
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
ACATA5 Acta Anatomica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1945-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CEFYAD Ceskoslovenska Fysiologie. (Academia, Vodickova 40, 112 29 Prague 1, Czechoslovakia) V.1- 1952-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.31- 1976-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NDKIA2 Kankyo Igaku Kenkyusho Nenpo (Nagoya Daigaku). Annual Report of the Research Institute of Environmental Medicine, Nagoya University. (Nagoya Daigaku Kankyo Igaku Kenkyusho, Furo-cho, Chikosa-ku, Nagoya 464, Japan) V.1- 1949-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PTPBD7 Pharmacology and Therapeutics, Part B: General and Systematic Pharmacology. (Oxford, UK) V.1-3, 1975-78. For publisher information, see PHTHDT.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in various oxidation processes, for feedstock and enrichment purposes

Top 50 chemical production: 42.38 billions lbs in 1992, 39.07 billions in 1991

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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