The Registry of Toxic Effects of Chemical Substances

Oxirane, ( (2 - propenyloxy) methyl) -

RTECS #: RR0875000

CAS #: 106-92-3

UPDATE: February 2005 MW: 114.16 MF: C6H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Epoxy - 3 - allyloxypropane
  2. 1 - (Allyloxy) - 2,3 - epoxypropane
  3. 1 - Allilossi - 2,3 epossipropano (Italian)
  4. 1 - Allyloxy - 2,3 - epoxy - propaan (Dutch)
  5. 1 - Allyloxy - 2,3 - epoxypropan (German)
  6. AGE (OSHA)
  7. Allil - glicidil - etere (Italian)
  8. Allyl 2,3 - epoxypropyl ether
  9. Allyl glycidol ether
  1. Allyl glycidyl ether
  2. Allyl glycidyl ether (ACGIH:OSHA)
  3. Allylglycidaether (German)
  4. Ether, allyl 2,3 - epoxypropyl
  5. Glycidyl allyl ether
  6. NCI - C56666
  7. Oxyde d'allyle et de glycidyle (French)
  8. Propane, 1 - (allyloxy) - 2,3 - epoxy -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		97 mg severe AMIHAB 14,250,1956
eye
rabbit 		750 µg/24 hour severe 85JCAE -,772,1986
skin
rabbit 		485 mg/3 day moderate AMIHAB 14,250,1956
skin
rabbit 		2 mg/24 hour severe 85JCAE -,772,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 64,800 µg/L NTPTR* NTP-TR-376,1990
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
mutation in microorganisms Escherichia coli 20 µmol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Klebsiella pneumoniae 500 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) NTPTR* NTP-TR-376,1990
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems Escherichia coli 3,300 µmol/L MUREAV 231,205,1990
sister chromatid exchange hamster ovary 3,300 µg/L NTPTR* NTP-TR-376,1990
sister chromatid exchange hamster lung 625 µmol/L MUREAV 249,55,1991
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		5,500 ppm ENMUDM 7,349,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 10 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors 		NTPTR* NTP-TR-376,1990
inhalation
mouse 		lowest published toxic concentration: 618 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		NTIS** PB90-260027
inhalation
rat 		lowest published toxic concentration: 10 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		NTPTR* NTP-TR-376,1990
inhalation
rat 		lowest published toxic concentration: 309 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		NTIS** PB90-260027


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 270 ppm/4 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		AMIHAB 14,250,1956
inhalation
rat 		lethal concentration (50 percent kill): 670 ppm/8 hour Eye: Corneal damage

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands 		AMIHAB 14,250,1956
oral
mouse 		lethal dose (50 percent kill): 390 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
oral
rat 		lethal dose (50 percent kill): 1,600 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		AMIHAB 14,250,1956
skin
rabbit 		lethal dose (50 percent kill): 2,550 mg/kg N/R AMIHAB 14,250,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 50 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-376,1990
inhalation
mouse 		lowest published toxic concentration: 309 mg/kg/103 week- intermittent Liver: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB90-260027
inhalation
mouse 		lowest published toxic concentration: 309 mg/kg/103 week- intermittent Brain and Coverings: Tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB90-260027
inhalation
rat 		lowest published toxic concentration: 400 ppm/7 hour/10 week- intermittent Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AMIHAB 14,250,1956
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour/14 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes 		NTPTR* NTP-TR-376,1990
intramuscular
rat 		lowest published toxic dose: 400 mg/kg/8 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AEHLAU 2,50,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (22 mg/m3) DTLWS* 3,9,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 10 ppm (45 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 10 ppm (45 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 10 ppm (45 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 10 ppm (45 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (22 mg/m3), short term exposure limit 10 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (23 mg/m3), short term exposure limit 10 ppm (47 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 10 ppm (45 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (45 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 10 ppm (45 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (45 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (24 mg/m3), short term exposure limit 10 ppm (47 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL GLYCIDYL ETHER-air 10 hour time-weighted average 5 ppm;
short term exposure limit 10 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 04530;
Number of Industries 9;
Total Number of Facilities 153;
Number of Occupations 24;
Total Number of Employees Exposed 2,769
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 04530;
Number of Industries 6;
Total Number of Facilities 23;
Number of Occupations 11;
Total Number of Employees Exposed 2,457;
Total Number of Female Employees Exposed 29


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NIOSH Analytical Method, 1994: Allyl glycidyl ether, 2545
NTP Carcinogenesis Studies (inhalation);some evidence:mouse NTPTR* NTP-TR-376,1990
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as a solvent and emulsifier

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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