The Registry of Toxic Effects of Chemical Substances

2 - Oxetanone, 4 - methylene -

RTECS #: RQ8225000

CAS #: 674-82-8

UPDATE: July 2000 MW: 84.08 MF: C4H4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 3 - Buteno - beta - lactone
  2. Diketene
  1. Ketene, dimer
  2. 4 - Methylene - 2 - oxetanone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,301,1986
eye
rabbit 		25 mg severe UCDS** 2/20/1963
eye
rabbit 		537 mg severe IHFCAY 6,1,1967
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,301,1986
skin
rabbit 		500 mg open irritation test mild UCDS** 2/20/1963
skin
rabbit 		537 mg mild IHFCAY 6,1,1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 3 gm/m3/2 hour N/R 85JCAE -,301,1986
inhalation
rat 		lowest published lethal concentration: 20,000 ppm/1 hour N/R IHFCAY 6,1,1967
oral
mouse 		lowest published lethal dose: 800 mg/kg N/R KODAK* 21MAY1971
oral
rat 		lethal dose (50 percent kill): 560 µL/kg N/R TXAPA9 28,313,1974
skin
guinea pig 		lowest published lethal dose: 10 mL/kg N/R KODAK* 21MAY1971
skin
rabbit 		lethal dose (50 percent kill): 2,830 µL/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69.
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Primary Irritant

ALT CAS #: 2130-41-8
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