The Registry of Toxic Effects of Chemical Substances
1,2 - Oxathiolane 2,2 - dioxide |
UPDATE: May 2005 | MW: 122.15 | MF: C3H6O3S |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
skin rabbit | 500 mg | mild | 34ZIAG -,498,1969 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster fibroblast | 125 mg/L/24 hour | MUREAV 48,337,1977 |
cytogenetic analysis | hamster lung | 10 mg/L | ATSUDG 4,41,1980 |
cytogenetic analysis | human lymphocyte | 1 mmol/L | TOLED5 28,139,1985 |
DNA adduct | Escherichia coli | 10 µmol/L | MUREAV 89,95,1981 |
DNA damage | Bacillus subtilis | 50 nmol/L | CNREA8 41,4368,1981 |
DNA damage | human fibroblast | 5 mg/L | CBINA8 22,185,1978 |
DNA damage |
intraperitoneal mouse | 200 mg/kg | MUREAV 467,83,2000 |
DNA damage |
intravenous rat | 31 mg/kg | TCMUD8 7,175,1987 |
DNA inhibition |
skin mouse | 2 mmol/kg | CNREA8 33,769,1973 |
DNA inhibition |
oral mouse | 20 gm/kg | ARGEAR 51,605,1981 |
DNA repair | Escherichia coli | 500 µg/disc | JJIND8 62,873,1979 |
DNA repair | other microorganisms | 610 µg/plate | BIZNAT 95,463,1976 |
unscheduled DNA synthesis | human fibroblast | 200 µmol/L/2 hour | 33AQAA -,103,1976 |
unscheduled DNA synthesis |
skin mouse | 2 mmol/kg | CNREA8 33,769,1973 |
host-mediated assay |
mouse
Salmonella typhimurium | 12 mg/kg | JJIND8 62,911,1979 |
mutation in microorganisms | Escherichia coli | 1 gm/L (-enzymatic activation step) | ATXKA8 28,93,1971 |
mutation in microorganisms | other microorganisms | 1,600 mg/L (-enzymatic activation step) | MOPMA3 6,667,1970 |
mutation in microorganisms | Salmonella typhimurium | 5 µg/plate (+enzymatic activation step) | JJIND8 62,893,1979 |
mutation in microorganisms | Salmonella typhimurium | 70 µg/plate (-enzymatic activation step) | PNASA6 72,5135,1975 |
mutation in microorganisms | Serratia marcescens | 25 mg/L (-enzymatic activation step) | ATXKA8 30,67,1972 |
mutation in microorganisms | Schizosaccharomyces pombe | 7,900 µmol/L (-enzymatic activation step) | CBINA8 14,195,1976 |
micronucleus test |
intraperitoneal mouse | 18 mg/kg/48 hour- intermittent | MUREAV 389,3,1997 |
gene conversion and mitotic recombination | Saccharomyes cerevisiae | 1,000 ppm | JJIND8 62,901,1979 |
mutation in mammalian somatic cells | human fibroblast | 30 mg/L | CNREA8 41,1620,1981 |
morphological transform |
intraperitoneal hamster | 1 gm/kg | ARPAAQ 95,380,1973 |
morphological transform | hamster kidney | 80 µg/L | BJCAAI 37,873,1978 |
morphological transform | hamster embryo | 1 mg/L | IJCNAW 19,642,1977 |
morphological transform | human other cell types | 7,500 µg/L | CNREA8 41,5096,1981 |
morphological transform | mouse fibroblast | 30 µg/L | CRNGDP 3,377,1982 |
morphological transform | mouse embryo | 50 mg/L | TOLED5 9,301,1981 |
morphological transform | rat embryo | 5 mg/L | JNCIAM 51,799,1973 |
other mutation test systems | Bacillus subtilis | 50 mmol/L | JOBAAY 136,854,1978 |
other mutation test systems | Salmonella typhimurium | 16 mg/L | MUREAV 192,239,1987 |
sister chromatid exchange | human lymphocyte | 500 µmol/L | TOLED5 28,139,1985 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intravenous rat | lowest published toxic dose: 80 mg/kg (15 day pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | IARCCD 4,45,1973 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intravenous rat | lowest published toxic dose: 20 mg/kg (15 day pregnant) |
Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Transplacental tumorigenesis Brain and Coverings: Tumors | IARCCD 4,45,1973 |
oral rat | lowest published toxic dose: 7,840 mg/kg/60 week- intermittent |
Tumorigenic: Carcinogenic by RTECS criteria Brain and Coverings: Tumors Skin and Appendages: Tumors | NATUAS 230,460,1971 |
oral rat | toxic dose : 1,100 mg/kg/37 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Peripheral Nerve and Sensation: Peripheral nerve tumors | ZEKBAI 75,69,1970 |
oral rat | toxic dose : 12 gm/kg/60 week- continuous |
Tumorigenic: Carcinogenic by RTECS criteria Brain and Coverings: Tumors Skin and Appendages: Tumors | JJIND8 67,75,1981 |
oral rat | toxic dose : 13 gm/kg/32 week- continuous |
Tumorigenic: Carcinogenic by RTECS criteria Brain and Coverings: Tumors Skin and Appendages: Tumors | JJIND8 67,75,1981 |
subcutaneous mouse | lowest published toxic dose: 756 mg/kg/63 week- intermittent |
Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application | JNCIAM 46,143,1971 |
subcutaneous rat | lowest published toxic dose: 10 mg/kg |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application | ZEKBAI 75,69,1970 |
subcutaneous rat | toxic dose : 166 mg/kg |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | INTSAO 66,161,1981 |
subcutaneous rat | toxic dose : 559 mg/kg/17 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | INTSAO 66,161,1981 |
subcutaneous rat | toxic dose : 434 mg/kg/15 week- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | INTSAO 66,161,1981 |
skin mouse | lowest published toxic dose: 1,000 mg/kg |
Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Lymphoma including Hodgkin's disease | TXCYAC 6,139,1976 |
skin mouse | toxic dose : 50 mg/kg/1 week- intermittent |
Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | TXAPA9 37,93,1976 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published lethal concentration: 2,140 mg/m3/6 hour |
Eye: Lacrimation Vascular: Regional or general arteriolar or venous dilation Skin and Appendages: Other: Hair | NTIS** OTS0555330 |
intraperitoneal mouse | lethal dose (50 percent kill): 100 mg/kg |
Eye: Other eye effects Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair | NTIS** OTS0555330 |
intraperitoneal rat | lethal dose (50 percent kill): 100 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea | NTIS** OTS0555330 |
oral mouse | lethal dose (50 percent kill): 400 mg/kg |
Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Skin and Appendages: Other: Hair | NTIS** OTS0555330 |
oral rat | lethal dose (50 percent kill): 100 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea | NTIS** OTS0555330 |
subcutaneous rat | lethal dose (50 percent kill): 135 mg/kg | N/R | ZEKBAI 75,69,1970 |
skin mouse | lowest published lethal dose: 1,000 gm/kg | N/R | TXCYAC 6,139,1976 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average L | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Confirmed Animal Carcinogen with Unknown | DTLVS* TLV/BEI,2003 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Sufficient Evidence | IMEMDT 4,253,1974 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Sufficient Evidence | IMEMDT 71,1095,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 4,253,1974 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 71,1095,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 2B | IMEMDT 71,1095,1999 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - AUSTRIA | Skin, Carcinogen, JAN1999 | |
Occupational Exposure Limit - GERMANY | Skin Carcinogen, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | Carcinogen, JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | Carcinogen, SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; Confirmed Animal Carcinogen with Unknown | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPANE SULTONE-air | Carcinogen lowest feasible concentration | NIOSH* DHHS #92-100,1992 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat | |
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo | |
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay | |
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test | |
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis | |
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion | |
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman | |
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast | |
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as an intermediate in the preparation of other compounds | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen |
REFERENCES: | |
CODEN |
REFERENCE |
33AQAA | "Biology of Radiation Carcinogenesis, Symposium, 1975," Yuhas, J.M., et al., eds., New York, Raven Press, 1976 |
34ZIAG | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 |
ARGEAR | Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- |
ARPAAQ | Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. |
ATSUDG | Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- |
ATXKA8 | Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. |
BIZNAT | Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- |
BJCAAI | British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- |
CBINA8 | Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- |
CNREA8 | Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- |
CRNGDP | Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
IARCCD | IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO. |
IJCNAW | International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
INTSAO | International Surgery. (International College of Surgeons, 1516 N. Lake Shore Dr., Chicago, IL 60610) V.45- 1966- |
JJIND8 | JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. |
JNCIAM | Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. |
JOBAAY | Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- |
MOPMA3 | Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NATUAS | Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
PNASA6 | Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- |
TCMUD8 | Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
TXCYAC | Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- |
ZEKBAI | Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. |