The Registry of Toxic Effects of Chemical Substances

Oxalic acid

RTECS #: RO2450000

CAS #: 144-62-7

UPDATE: November 2004 MW: 90.04 MF: C2H2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acide oxalique (French)
  2. Acido ossalico (Italian)
  3. Aktisal
  4. Aquisal
  5. Oxaalzuur (Dutch)
  6. Ethanedioic acid
  1. Ethanedionic acid
  2. Kyselina stavelova (Czech)
  3. NCI - C55209
  4. Oxalic acid (ACGIH:OSHA)
  5. Oxalsaeure (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,311,1986
eye
rabbit 		100 mg/4S rinse severe FCTOD7 20,573,1982
skin
rabbit 		500 mg/24 hour mild 85JCAE -,311,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 8,400 mg/kg (7 day male/7 day prior to copulation-21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** PB86-167053
oral
mouse 		lowest published toxic dose: 9.63 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB86167053
oral
mouse 		lowest published toxic dose: 275 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NTIS** #PB86167053


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 270 mg/kg N/R TXCYAC 62,203,1990
oral
dog 		lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1377,1935
oral
rat 		lethal dose (50 percent kill): 7,500 mg/kg N/R TXAPA9 42,417,1977
oral
woman 		lowest published lethal dose: 600 mg/kg Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes 		YKYUA6 31,959,1980
subcutaneous
cat 		lowest published lethal dose: 112 mg/kg N/R HBAMAK 4,1377,1935
subcutaneous
frog 		lowest published lethal dose: 757 mg/kg N/R HBAMAK 4,1377,1935
unreported route
rat 		lethal dose (50 percent kill): 382 mg/kg N/R HBPTO* 1,824,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,268 mg/kg/14 day- continuous Behavioral: Fluid intake NTIS** #PB86167053
oral
mouse 		lowest published toxic dose: 40,425 mg/kg/21 week- continuous Related to Chronic Data: Changes in prostate weight NTIS** #PB86167053
oral
rat 		lowest published toxic dose: 175 gm/kg/70 day- continuous Endocrine: Changes in thyroid weight

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 48,409,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 2 mg/m3 DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
FNSCA6 2,67,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,329,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg/m3 DTLVS* 3,193,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 mg/m3, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 mg/m3, KTV 2 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 mg/m3, short term exposure limit 0.2 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 2 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 2 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OXALIC ACID-air 10 hour time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 52480;
Number of Industries 109;
Total Number of Facilities 11,395;
Number of Occupations 66;
Total Number of Employees Exposed 180,732
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 52480;
Number of Industries 75;
Total Number of Facilities 6,866;
Number of Occupations 84;
Total Number of Employees Exposed 142,000;
Total Number of Female Employees Exposed 58,727


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in textile finishing, stripping, metal and equipment cleaning and as an intermediate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in textile finishing, stripping, metal and equipment cleaning and as an intermediate

NIOSH PROFILE (GLASS and CERAMICS MANUFACTURE), SRC, 6/80

NIOSH PROFILE (OXALIC ACID), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector
   Human Data
   Primary Irritant

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