The Registry of Toxic Effects of Chemical Substances

7 - Oxabicyclo (4.1.0) heptane, 3 - (epoxyethyl) -

RTECS #: RN8640000

CAS #: 106-87-6

UPDATE: May 2005 MW: 140.20 MF: C8H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Epoxy - 4 - (epoxyethyl) cyclohexane
  2. 1 - Epoxyethyl - 3,4 - epoxycyclohexane
  3. 1 - Ethyleneoxy - 3,4 - epoxycyclohexane
  4. 1 - Vinyl - 3 - cyclohexene dioxide
  5. 3 - (1,2 - Epoxyethyl) - 7 - oxabicyclo (4.1.0) heptane
  6. 3 - Oxiranyl - 7 - oxabicyclo (4.1.0) heptane
  7. 4 - (1,2 - Epoxyethyl) - 7 - oxabicyclo (4.1.0) heptane
  8. 4 - Vinlycyclohexene dioxide
  9. 4 - Vinyl - 1,2 - cyclohexene diepoxide
  1. 4 - Vinyl - 1 - cyclohexene diepoxide
  2. 4 - Vinyl - 1 - cyclohexene dioxide
  3. 4 - Vinylcyclohexene
  4. 4 - Vinylcyclohexene diepoxide
  5. NCI - C60139
  6. UCET textile finish 11 - 74 (Obs.)
  7. Vinyl cyclohexene diepoxide
  8. Vinyl cyclohexene dioxide
  9. Vinylcyclohexene diepoxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg severe SCCUR* -,9,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 37,800 picograms/kg NTPTR* NTP-TR-362,1989
cytogenetic analysis intraperitoneal
rat 		125 mg/kg BJPCAL 6,235,1951
DNA damage intraperitoneal
rat 		960 mg/kg TXAPA9 139,394,1996
mutation in microorganisms Klebsiella pneumoniae 1 mmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+/-enzymatic activation step) MUREAV 66,367,1979
mutation in microorganisms Saccharomyes cerevisiae 25 mmol/L (-enzymatic activation step) BSIBAC 56,1803,1980
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L BSIBAC 56,1803,1980
mutation in mammalian somatic cells mouse lymphocyte 25 ng/kg NTPTR* NTP-TR-362,1989
sister chromatid exchange hamster ovary 3,730 picograms/kg NTPTR* NTP-TR-362,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 4,800 mg/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Other effects on male 		TOXID9 12,435,1992
oral
mouse 		lowest published toxic dose: 13,468 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system 		TOXID9 14,164,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 5,000 mg/kg/10 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application 		BJPCAL 6,235,1951
skin
mouse 		lowest published toxic dose: 56 gm/kg/47 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 31,41,1963
skin
mouse 		toxic dose : 90 gm/kg/74 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		AIHAAP 24,305,1963
skin
mouse 		toxic dose : 12 gm/kg/9 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		BJPCAL 6,235,1951
skin
mouse 		toxic dose : 10,300 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors 		NTPTR* NTP-TR-362,1989
skin
mouse 		lowest published toxic dose: 60,000 mg/kg/60 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB90-219957/AS
skin
mouse 		lowest published toxic dose: 60,000 mg/kg/60 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Maternal effects: Ovaries, fallopian tubes 		NTIS** PB90-219957/AS
skin
mouse 		lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB90-219957/AS
skin
mouse 		lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors 		NTIS** PB90-219957/AS
skin
rat 		lowest published toxic dose: 31,500 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTPTR* NTP-TR-362,1989
skin
rat 		lowest published toxic dose: 31,500 mg/kg/105 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB90-219957/AS
skin
rat 		lowest published toxic dose: 39,375 mg/kg/105 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB90-219957/AS
unreported route
mouse 		lowest published toxic dose: 2,800 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors 		RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 800 ppm/4 hour N/R SCCUR* -,9,1961
intraperitoneal
rat 		lowest published toxic dose: 80 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		BIREBV 67,718,2002
intraperitoneal
rat 		lowest published toxic dose: 320 mg/kg Reproductive: Maternal effects: Oogenesis REPTED 19,71,2004
oral
rat 		lethal dose (50 percent kill): 2,130 mg/kg N/R SCCUR* -,9,1961
skin
mouse 		lowest published lethal dose: 3,216 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Skin: After systemic exposure: Dermatitis, other 		NTPTR* NTP-TR-362,1989
skin
rabbit 		lethal dose (50 percent kill): 620 µL/kg N/R UCDS** 9/19/1972
unreported route
rabbit 		lethal dose (50 percent kill): 680 µg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Other changes 		BSIBAC 56,1803,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 400 mg/kg/10 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AEHLAU 2,50,1961
intraperitoneal
mouse 		lowest published toxic dose: 4,000 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight 		REPTED 9,359,1995
intraperitoneal
mouse 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 5,379,1991
intraperitoneal
rat 		lowest published toxic dose: 2,400 mg/kg/30 day- intermittent Endocrine: Change in gonadotropins

Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Menstrual cycle changes or disorders 		REPTED 16,775,2002
intraperitoneal
rat 		lowest published toxic dose: 800 mg/kg/10 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		BIREBV 67,718,2002
intraperitoneal
rat 		lowest published toxic dose: 1,200 mg/kg/15 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TXAPA9 184,107,2002
oral
mouse 		lowest published toxic dose: 65 gm/kg/13 week- intermittent Gastrointestinal: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		FAATDF 14,745,1990
oral
rat 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Gastrointestinal: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		FAATDF 14,745,1990
oral
rat 		lowest published toxic dose: 560 mg/kg/2 week- continuous Reproductive: Maternal effects: Oogenesis REPTED 17,273,2003
skin
mouse 		lowest published toxic dose: 6,832 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Skin: After systemic exposure: Dermatitis, other 		NTPTR* NTP-TR-362,1989
skin
mouse 		lowest published toxic dose: 26 gm/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Skin: After systemic exposure: Dermatitis, other 		NTPTR* NTP-TR-362,1989
skin
rat 		lowest published toxic dose: 6,552 mg/kg/14 day- intermittent Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight 		NTPTR* NPT-TR-362,1989
skin
rat 		lowest published toxic dose: 19,500 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other glands 		FAATDF 14,745,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 11,141,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,361,1994
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 11,141,1976
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,361,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 60,361,1994


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (60 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (57 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (60 mg/m3), short term exposure limit 20 ppm (120 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 10ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 60 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM LTEL 10 ppm (60 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL CYCLOHEXENE DIOXIDE-air Carcinogen;
10 hour time-weighted average 10 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1392;
Number of Industries 7;
Total Number of Facilities 181;
Number of Occupations 11;
Total Number of Employees Exposed 2,028
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1392;
Number of Industries 14;
Total Number of Facilities 107;
Number of Occupations 24;
Total Number of Employees Exposed 6,224;
Total Number of Female Employees Exposed 1,718


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a chemical intermediate and as a reactive diluent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a chemical intermediate and as a reactive diluent

NIOSH PROFILE (VINYL CYCLOHEXENE DIOXIDE), SRC, 14/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 25550-49-6
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