The Registry of Toxic Effects of Chemical Substances

1,6 - Octadien - 3 - ol, 3,7 - dimethyl -

RTECS #: RG5775000

CAS #: 78-70-6

UPDATE: August 2004 MW: 154.28 MF: C10H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. allo - Ocimenol
  2. 2,6 - Dimethylocta - 2,7 - dien - 6 - ol
  3. 3,7 - Dimethylocta - 1,6 - dien - 3 - ol
  1. 3,7 - Dimethyl - 1,6 - octadien - 3 - ol
  2. Linalool
  3. Linalyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL moderate NTIS** OTS0543729
skin
guinea pig 		100 mg/24 hour moderate CTOIDG 94(8),41,1979
skin
man 		16 mg/48 hour mild CTOIDG 94(8),41,1979
skin
rabbit 		500 mg/24 hour mild FCTXAV 14,673,1976
skin
rabbit 		100 mg/24 hour severe CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 8,622 µg/disc OIGZDE 34,267,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 8 gm/kg N/R JSICAZ 21,342,1962
intraperitoneal
mouse 		lethal dose (50 percent kill): 340 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		IIFBA4 15,149,1973
intraperitoneal
rat 		lethal dose (50 percent kill): 307 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		IIFBA4 15,149,1973
oral
mouse 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0543729
oral
rat 		lethal dose (50 percent kill): 2,790 mg/kg Behavioral: Ataxia FCTXAV 2,327,1964
subcutaneous
mouse 		lethal dose (50 percent kill): 1,470 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change SIZSAR 3,73,1952
skin
rat 		lethal dose (50 percent kill): 5,610 mg/kg N/R 85JCAE -,202,1986
skin
rabbit 		lethal dose (50 percent kill): 5,610 mg/kg N/R FCTXAV 13,827,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
FCTOD7 41,919,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,379,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4982;
Number of Industries 2;
Total Number of Facilities 37;
Number of Occupations 16;
Total Number of Employees Exposed 2,301
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4982;
Number of Industries 106;
Total Number of Facilities 16,058;
Number of Occupations 118;
Total Number of Employees Exposed 245,476;
Total Number of Female Employees Exposed 109,311


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as fragrance raw material and raw material source for acetate production
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IIFBA4 Izvestiya na Instituta po Fiziologiya, Bulgarska Akademiya na Naukite. (Sofia, Bulgaria) V.4-16, 1960-74. For publisher information, see APPBDI.
JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SIZSAR Sapporo Igaku Zasshi. Sapporo Medical Journal. (Sapporo Igaku Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan) V.3- 1952-

Used as fragrance raw material and raw material source for acetate production

RTECS Compound Description:
   Mutagen
   Primary Irritant

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