The Registry of Toxic Effects of Chemical Substances

9 - Octadecenoic acid, (Z) -

RTECS #: RG2275000

CAS #: 112-80-1

UPDATE: August 2003 MW: 282.52 MF: C18H34O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acide oleique (French)
  2. Emersol 210
  3. Emersol 213
  4. Emersol 6321
  5. Emersol 233LL
  6. Emersol 221 low titer white oleic acid
  7. Emersol 220 white oleic acid
  8. Glycon RO
  9. Glycon WO
  10. Groco 2
  11. Groco 4
  12. Groco 6
  13. Groco 5L
  14. HY - Phi 1055
  15. HY - Phi 1088
  16. HY - Phi 2066
  1. HY - Phi 2088
  2. HY - Phi 2102
  3. Industrene 105
  4. Industrene 205
  5. Industrene 206
  6. cis - Octadec - 9 - enoic acid
  7. Oleic acid
  8. Oleinic acid
  9. Pamolyn
  10. Tego - oleic 130
  11. Vopcolene 27
  12. Wecoline OO
  13. Wochem No. 320
  14. cis - delta (sup 9) - Octadecenoic acid
  15. cis - 9 - Octadecenoic acid
  16. 9 - Octadecenoic acid, cis -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild JACTDZ 6(3),321,1987
skin
human 		15 mg/3 day- intermittent moderate 85DKA8 -,127,1977
skin
rabbit 		500 mg open irritation test mild UCDS** 11/29/1963


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 2,500 µg/L CRNGDP 3,499,1982
cytogenetic analysis Saccharomyes cerevisiae 100 mg/L NATUAS 294,263,1981
unscheduled DNA synthesis rectal
mouse 		35 mg/kg CALEDQ 23,253,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rabbit 		lowest published toxic dose: 390 mg/kg/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		CRSBAW 137,760,1943


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 282 mg/kg N/R YKKZAJ 104,793,1984
intravenous
monkey 		lethal dose : >40 µL/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		LUNGD9 164,259,1986
intravenous
mouse 		lethal dose (50 percent kill): 230 mg/kg Behavioral: Convulsions or effect on seizure threshold APTOA6 18,141,1961
intravenous
rat 		lethal dose (50 percent kill): 2,400 µg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes 		AJPAA4 103,376,1981
intravenous
rabbit 		lethal dose : >55 mg/kg Lung, Thorax, or Respiration: Other changes ARDSBL 137(Suppl),226,1988
oral
mouse 		lethal dose (50 percent kill): 28 gm/kg N/R TOVEFN (1),39,2000
oral
rat 		lethal dose (50 percent kill): 25 gm/kg N/R TOVEFN (1),39,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,336,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 52190;
Number of Industries 312;
Total Number of Facilities 65,952;
Number of Occupations 196;
Total Number of Employees Exposed 796,897
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 52190;
Number of Industries 256;
Total Number of Facilities 49,332;
Number of Occupations 181;
Total Number of Employees Exposed 1,078,478;
Total Number of Female Employees Exposed 410,362


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for inks, alkyds, adhesives, soaps, soluble cutting oils, rubber compounding, cleaners
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
LUNGD9 Lung. (Springer-Verlag New York, POB 2485, Secaucus, NJ 07096) V.154- 1976-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used for inks, alkyds, adhesives, soaps, soluble cutting oils, rubber compounding, cleaners

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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