The Registry of Toxic Effects of Chemical Substances

2 - Norbornene, 5 - ethylidene -

RTECS #: RB9450000

CAS #: 16219-75-3

UPDATE: November 2004 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 5 - Ethylidene - 2 - norbornene
  2. 5 - Ethylidenebicyclo (2.2.1) hept - 2 - ene
  3. Bicyclo (2.2.1) hept - 2 - ene, 5 - ethylidene - (9CI)
  1. Ethylidene norbornene
  2. Ethylidene norbornene (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		445 mg open irritation test mild UCDS** 11/28/1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		IOMTE3 4,371,1995


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration (50 percent kill): 15,600 mg/m3/90 minute N/R VCVGH* -,104,1990
inhalation
dog 		lowest published toxic concentration: 10,500 mg/m3/30 minute Behavioral: Convulsions or effect on seizure threshold

Skin: After topical application: Primary irritation 		VCVGH* -,104,1990
inhalation
dog 		lowest published toxic concentration: 6,200 mg/m3/90 minute Behavioral: Convulsions or effect on seizure threshold VCVGH* -,104,1990
inhalation
guinea pig 		lethal concentration (50 percent kill): 2,896 ppm/4 hour Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 20,250,1971
inhalation
human 		lowest published toxic concentration: 6 ppm/30 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Taste: Change in function 		TXAPA9 20,250,1971
inhalation
human 		lowest published toxic concentration: 27 mg/m3/30 minute Eye: Conjunctiva irritation VCVGH* -,104,1990
inhalation
mouse 		lethal concentration (50 percent kill): 732 ppm/4 hour Behavioral: Muscle weakness TXAPA9 20,250,1971
inhalation
mouse 		lethal concentration (50 percent kill): 10,900 mg/m3/2 hour N/R VCVGH* -,104,1990
inhalation
rat 		lethal concentration (50 percent kill): 1,246 ppm/4 hour Behavioral: Muscle weakness TXAPA9 20,250,1971
inhalation
rat 		lethal concentration (50 percent kill): 3,520 mg/m3/4 hour N/R VCVGH* -,104,1990
inhalation
rabbit 		lethal concentration (50 percent kill): 3,104 ppm/4 hour Olfaction: Ulcerated nasal septum TXAPA9 20,250,1971
intraperitoneal
rat 		lethal dose (50 percent kill): 2,830 µL/kg N/R NTIS** OTS0536403
oral
mouse 		lethal dose (50 percent kill): 3,040 mg/kg N/R VCVGH* -,104,1990
oral
rat 		lethal dose (50 percent kill): 2,830 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lethal dose (50 percent kill): 5.66 mL/kg N/R VCVGH* -,104,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 61 ppm/7 hour/89 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		NTIS** OTS0536403
inhalation
rat 		lowest published toxic concentration: 90 ppm/7 hour/88 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 20,250,1971
inhalation
rat 		lowest published toxic concentration: 350 ppm/6 hour/11 day- intermittent Endocrine: Changes in thyroid weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536403
inhalation
rat 		lowest published toxic concentration: 52 ppm/6 hour/9 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Evidence of thyroid hyperfunction 		JJATDK 17,197,1997
inhalation
rat 		lowest published toxic concentration: 359 ppm/6 hour/66 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition JJATDK 17,197,1997
inhalation
rat 		lowest published toxic concentration: 149 ppm/6 hour/66 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Changes in liver weight 		JJATDK 17,197,1997
inhalation
rat 		lowest published toxic concentration: 359 ppm/6 hour/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JJATDK 17,197,1997
inhalation
rat 		lowest published toxic concentration: 24.8 ppm/6 hour/66 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JJATDK 17,197,1997
inhalation
rat 		lowest published toxic concentration: 50 ppm/6 hour/9 day- intermittent Endocrine: Other changes JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 150 ppm/6 hour/9 day- intermittent Liver: Other changes

Endocrine: Changes in thyroid weight 		JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 359 ppm/6 hour/9 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Normocytic anemia 		JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 50 ppm/6 hour/9 day- intermittent Endocrine: Changes in thyroid weight JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 359 ppm/6 hour/9 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 4.9 ppm/6 hour/14 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 24.8 ppm/6 hour/14 week- intermittent Endocrine: Other changes

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 149 ppm/6 hour/14 week- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Changes in liver weight 		JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 4.9 ppm/6 hour/14 week- intermittent Eye: Other eye effects JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 24.8 ppm/6 hour/14 week- intermittent Blood: Changes in erythrocyte (RBC) count JAPTO* 17,197,1997
inhalation
rat 		lowest published toxic concentration: 149 ppm/6 hour/14 week- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in kidney weight 		JAPTO* 17,197,1997
oral
rat 		lowest published toxic dose: 4,200 mg/kg/14 day- continuous Liver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0538294-1


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM short term exposure limit 5 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 25 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLIDENE NORBORNENE-air ceiling concentration 5 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3889;
Number of Industries 1;
Total Number of Facilities 22;
Number of Occupations 20;
Total Number of Employees Exposed 1,988


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as the third monomer in terpolymer elastomers
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IOMTE3 International Journal of Occupational Medicine and Toxicology. (Princeton Scientific Publishing, POB 2155, Princeton, NJ 08543) V.3(2)- 4(4), 1994-95
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as the third monomer in terpolymer elastomers

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

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