The Registry of Toxic Effects of Chemical Substances

5 - Norbornene - 2,3 - dicarboxylic anhydride, 1,4,5,6,7,7 - hexachloro -

RTECS #: RB9080000

CAS #: 115-27-5

UPDATE: December 1998 MW: 370.81 MF: C9H2Cl6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Chloran 542
  2. Chlorendic anhydride
  1. HET anhydride
  2. 4,7 - Methanoisobenzofuran - 1,3 - dione, 4,5,6,7,8,8 - hexachloro - 3a,4,7,7a - tetrahydro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe NTIS** OTS0537102


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): >1 gm/m3 N/R GTPZAB 26(4),49,1982
inhalation
rat 		lethal concentration (50 percent kill): >1 gm/m3 N/R GTPZAB 26(4),49,1982
inhalation
rabbit 		lethal concentration (50 percent kill): >1 gm/m3 N/R GTPZAB 26(4),49,1982
oral
mouse 		lethal dose (50 percent kill): 2,400 mg/kg N/R GTPZAB 26(4),49,1982
oral
rat 		lethal dose (50 percent kill): 2,300 mg/kg N/R GTPZAB 26(4),49,1982
skin
rabbit 		lethal dose (50 percent kill): >3 gm/kg N/R NTIS** OTS0537102


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 51,500 µg/m3/30 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Other changes 		GTPZAB 26(4),49,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3595;
Number of Industries 2;
Total Number of Facilities 57;
Number of Occupations 3;
Total Number of Employees Exposed 686;
Total Number of Female Employees Exposed 237


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Primary Irritant

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