The Registry of Toxic Effects of Chemical Substances
Nonane |
UPDATE: November 2004 | MW: 128.29 | MF: C9H20 |
SYNONYMS: | |
|
|
SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
skin pig | 250 無/24 hour | mild | TXCYAC 161,1,2001 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lethal concentration (50 percent kill): 3,200 ppm/4 hour | N/R | TXAPA9 44,53,1978 |
inhalation rat | lethal concentration (50 percent kill): 17,000 mg/m3/4 hour | N/R | VCVGH* -,39,1990 |
intravenous mouse | lethal dose (50 percent kill): 218 mg/kg | N/R | JPMSAE 67,566,1978 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 1,600 ppm/6 hour/13 week- intermittent |
Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 44,53,1978 |
inhalation rat | lowest published toxic concentration: 8,100 mg/m3/6 hour/1 week- intermittent |
Eye: Conjunctiva irritation Behavioral: Tremor Behavioral: Ataxia | VCVGH* -,39,1990 |
inhalation rat | lowest published toxic concentration: 8,400 mg/m3/6 hour/63 day- intermittent |
Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | VCVGH* -,39,1990 |
intraperitoneal rat | lowest published toxic dose: 5 mg/kg/7 day- intermittent |
Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | ENVRAL 22,271,1980 |
oral mouse | lowest published toxic dose: 90 gm/kg/90 day- intermittent |
Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | TOXID9 54,397,2000 |
oral rat | lowest published toxic dose: 90 gm/kg/90 day- intermittent |
Endocrine: Changes in adrenal weight Related to Chronic Data: Changes in ovarian weight | TOXID9 54,397,2000 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 200 ppm | DTLVS* TLV/BEI,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - DENMARK | time-weighted average 200 ppm (1050 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 200 ppm (1050 mg/m3), short term exposure limit 250 ppm (1315 mg/m3), JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 200 ppm (1050 mg/m3), JAN1999 | |
Occupational Exposure Limit - JAPAN | Occupational Exposure Limit 200 ppm (1050 mg/m3), JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 100 ppm (525 mg/m3), JAN1999 | |
Occupational Exposure Limit - SWEDEN | NGV 150 ppm (800 mg/m3), KTV 200 ppm (1100 mg/m3), JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 200 ppm (1050 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 1050 mg/m3, 2003 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 200 ppm | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NONANE-air | 10 hour time-weighted average 200 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: M4718; Number of Industries 2; Total Number of Facilities 57; Number of Occupations 2; Total Number of Employees Exposed 1,231 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: M4718![]() Number of Industries 14; Total Number of Facilities 738; Number of Occupations 16; Total Number of Employees Exposed 7,277; Total Number of Female Employees Exposed 717 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used in organic synthesis, as a distillation chaser and in biodegradable detergents | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
ENVRAL | Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- |
JPMSAE | Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
TOXID9 | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
TXCYAC | Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- |
VCVGH* | "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990. |