The Registry of Toxic Effects of Chemical Substances

Nonane

RTECS #: RA6115000

CAS #: 111-84-2

UPDATE: November 2004 MW: 128.29 MF: C9H20


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Shellsol 140
  2. Nonane (ACGIH)
  1. n - Nonane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
pig 		250 µL/24 hour mild TXCYAC 161,1,2001


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 3,200 ppm/4 hour N/R TXAPA9 44,53,1978
inhalation
rat 		lethal concentration (50 percent kill): 17,000 mg/m3/4 hour N/R VCVGH* -,39,1990
intravenous
mouse 		lethal dose (50 percent kill): 218 mg/kg N/R JPMSAE 67,566,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,600 ppm/6 hour/13 week- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 44,53,1978
inhalation
rat 		lowest published toxic concentration: 8,100 mg/m3/6 hour/1 week- intermittent Eye: Conjunctiva irritation

Behavioral: Tremor

Behavioral: Ataxia 		VCVGH* -,39,1990
inhalation
rat 		lowest published toxic concentration: 8,400 mg/m3/6 hour/63 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		VCVGH* -,39,1990
intraperitoneal
rat 		lowest published toxic dose: 5 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		ENVRAL 22,271,1980
oral
mouse 		lowest published toxic dose: 90 gm/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		TOXID9 54,397,2000
oral
rat 		lowest published toxic dose: 90 gm/kg/90 day- intermittent Endocrine: Changes in adrenal weight

Related to Chronic Data: Changes in ovarian weight 		TOXID9 54,397,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (1050 mg/m3), short term exposure limit 250 ppm (1315 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (525 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN NGV 150 ppm (800 mg/m3), KTV 200 ppm (1100 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (1050 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1050 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NONANE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4718;
Number of Industries 2;
Total Number of Facilities 57;
Number of Occupations 2;
Total Number of Employees Exposed 1,231
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4718;
Number of Industries 14;
Total Number of Facilities 738;
Number of Occupations 16;
Total Number of Employees Exposed 7,277;
Total Number of Female Employees Exposed 717


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in organic synthesis, as a distillation chaser and in biodegradable detergents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in organic synthesis, as a distillation chaser and in biodegradable detergents

RTECS Compound Description:
   Drug
   Primary Irritant

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