The Registry of Toxic Effects of Chemical Substances

Nitroglycerin

RTECS #: QX2100000

CAS #: 55-63-0

UPDATE: November 2004 MW: 227.11 MF: C3H5N3O9


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Angibid
  2. Anginine
  3. Angiolingual
  4. Angorin
  5. Glonoin
  6. Gilucor nitro
  7. Myocon
  8. Myoglycerin
  9. NG
  10. Niglin
  11. Niglycon
  12. Niong
  13. Nitora
  14. Nitric acid triester of glycerol
  15. Nitrin
  16. Nitrine
  17. Nitrine - TDC
  18. Nitro - dur
  19. Nitroglicerina (Italian)
  20. Nitrogliceryna (Polish)
  21. Blasting gelatin
  22. Blasting oil
  23. Cardamist
  24. Glycerintrinitrate (Czech)
  25. Glycerol, nitric acid triester
  26. Glyceroltrinitraat (Dutch)
  27. Glycerol trinitrate
  28. Glycerol (trinitrate de) (French)
  29. Glyceryl nitrate
  30. Glyceryl trinitrate
  31. GTN
  32. Klavikordal
  33. Lenitral
  34. Nitronet
  35. Nitrong
  36. RCRA waste number P081
  37. Nitroglycerin (ACGIH:OSHA)
  38. Nitroglycerin - ACC
  1. Nitroglycerine
  2. Nitroglycerin, spirits of
  3. Nitroglycerol
  4. Nitroglyn
  5. Nitrolan
  6. Nitro - lent
  7. Nitroletten
  8. Nitrolingual
  9. Nitrolowe
  10. Nitromel
  11. Nitrorectal
  12. Nitro - span
  13. Nitrostabilin
  14. Nitrostat
  15. Nitrozell retard
  16. NK - 843
  17. Nysconitrine
  18. NTG
  19. Perglottal
  20. Propanetriol trinitrate
  21. 1,2,3 - Propanetriol, trinitrate (9CI)
  22. 1,2,3 - Propanetriyl nitrate
  23. SK - 106N
  24. S.N.G
  25. Solution glyceryl trinitrate
  26. Soup
  27. Spirit of glonoin
  28. Spirit of glyceryl trinitrate
  29. Spirit of trinitroglycerin
  30. Temponitrin
  31. TNG
  32. Trinalgon
  33. Trinitrin
  34. Trinitroglycerin
  35. Trinitroglycerol
  36. Trinitrol
  37. Vasoglyn


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour mild NTIS** AD-B011-150


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition cattle mammary gland 30 µmol/L/24 hour MOCAE8 59,1044,2001
mutation in microorganisms Salmonella typhimurium 2,500 nmol/plate (+enzymatic activation step) MUREAV 298,187,1993
mutation in microorganisms Salmonella typhimurium 50 µg/well (-enzymatic activation step) CBINA8 19,77,1977
mutation in mammalian somatic cells human other cell types 800 µmol/L/24 hour EMMUEG 38,261,2001
mutation in mammalian somatic cells intraperitoneal
mouse 		5 mg/kg JJIND8 92,1429,2000
specific locus test human other cell types 800 µmol/L/24 hour EMMUEG 38,261,2001
specific locus test intraperitoneal
mouse 		5 mg/kg JJIND8 92,1429,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 11 mg/kg (7-17 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death 		YACHDS 13,3807,1985
intraperitoneal
rat 		lowest published toxic dose: 220 mg/kg (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		YACHDS 13,3807,1985
intraperitoneal
rat 		lowest published toxic dose: 2,580 mg/kg (91 day male/2 week prior to copulation-7 day pregnant) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Other effects to embryo or fetus 		YACHDS 13,3783,1985
intraperitoneal
rat 		lowest published toxic dose: 520 mg/kg (17 day pregnant-20 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) YACHDS 13,3843,1985
skin
rat 		lowest published toxic dose: 3,640 mg/kg (17-21 day pregnant/21 day after birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		KSRNAM 18,3564,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 36,500 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		ATSUDG 4,88,1980
oral
rat 		toxic dose : 438 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		ATSUDG 4,88,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 104 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		IYKEDH 13,90,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 102 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		IYKEDH 13,90,1982
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Analgesia EJPHAZ 464,159,2003
intraperitoneal
rabbit 		lethal dose (50 percent kill): 189 mg/kg N/R NIIRDN -,786,1990
intravenous
cat 		lowest published toxic dose: 1 mg/kg Cardiac: Other changes

Vascular: BP lowering not characterized in autonomic section

Vascular: Measurement of regional blood flow 		FATOAO 47,55,1984
intravenous
cat 		lowest published lethal dose: 5 mg/kg Cardiac: Change in conduction velocity

Vascular: BP lowering not characterized in autonomic section 		FATOAO 47,55,1984
intravenous
cat 		lowest published toxic dose: 0.5 mg/kg Cardiac: Change in force of contraction

Cardiac: Pulse rate increased without fall in BP

Vascular: BP lowering not characterized in autonomic section 		FATOAO 44,174,1981
intravenous
dog 		lethal dose (50 percent kill): 19 mg/kg Eye: Hemorrhage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		OYYAA2 22,629,1981
intravenous
man 		lowest published toxic dose: 51,429 µg/kg/2 day- intermittent Brain and Coverings: Encephalitis

Eye: Miosis (pupilliary constriction)

Eye: Corneal damage 		AIMEAS 101,500,1984
intravenous
man 		lowest published toxic dose: 7.14 ng/kg Vascular: Regional or general arteriolar or venous dilation CLPTAT 67,22,2000
intravenous
mouse 		lethal dose (50 percent kill): 10,600 µg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		IYKEDH 13,90,1982
intravenous
mouse 		lethal dose (50 percent kill): 30 mg/kg N/R FATOAO 47,55,1984
intravenous
rat 		lethal dose (50 percent kill): 23,200 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia 		JJATDK 3,161,1983
intravenous
rat 		lowest published toxic dose: 8 µg/kg Vascular: BP lowering not characterized in autonomic section BIPBU* 24,1370,2001
intravenous
rat 		lowest published toxic dose: 1,714.3 µg/kg/1 hour Behavioral: Tolerance AAPSP* 4,10,2002
intravenous
rabbit 		lethal dose (50 percent kill): 45 mg/kg N/R NIIRDN 6,547,1982
oral
guinea pig 		lethal dose (50 percent kill): 1,450 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia 		STGNBT -,180,1999
oral
human 		lowest published toxic dose: 0.83 mg/kg Cardiac: Change in rate

Vascular: Measurement of regional blood flow 		FATOAO 49,84,1986
oral
mouse 		lethal dose (50 percent kill): 115 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
oral
rat 		lethal dose (50 percent kill): 105 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
oral
rat 		lowest published toxic dose: 1,360 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Tetany

Cardiac: Cardiomyopathy including infarction 		FATOAO 48,76,1985
oral
rabbit 		lethal dose (50 percent kill): 1,607 mg/kg N/R NIIRDN -,786,1990
oral
woman 		lowest published toxic dose: 8 µg/kg Behavioral: Headache

Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting 		AJEMEN 11,253,1993
oral
woman 		lowest published toxic dose: 8 µg/kg Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes 		AEMED3 23,31,1994
oral
woman 		lowest published toxic dose: 5 mg/kg Behavioral: General anesthetic

Cardiac: Other changes

Kidney, Ureter, and Bladder: Incontinence 		NAYXEW 8,181,1988
subcutaneous
cat 		lowest published lethal dose: 150 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia 		AEPPAE 200,271,1942
subcutaneous
mouse 		lethal dose (50 percent kill): 110 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
subcutaneous
rat 		lethal dose (50 percent kill): 94 mg/kg Behavioral: Somnolence (general depressed activity) YACHDS 13,3649,1985
subcutaneous
rabbit 		lowest published lethal dose: 400 mg/kg N/R AEPPAE 200,271,1942
skin
mouse 		lethal dose (50 percent kill): >35,200 µg/kg N/R NIIRDN -,786,1990
skin
rat 		lethal dose (50 percent kill): >29,200 µg/kg N/R NIIRDN -,786,1990
skin
rabbit 		lethal dose (50 percent kill): >280 mg/kg N/R NIIRDN -,786,1990
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 230 mg/kg N/R FRXXBL #2454807


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 86 µg/m3/17 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Fatty liver degeneration

Cardiac: EKG changes not diagnostic of above 		STGNBT -,180,1999
intraperitoneal
rat 		lowest published toxic dose: 825 mg/kg/33 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		YACHDS 13,3689,1985
intraperitoneal
rat 		lowest published toxic dose: 1,575 mg/kg/13 week- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Changes in: K

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		YACHDS 13,3753,1985
intravenous
dog 		lowest published toxic dose: 300 mg/kg/30 day- intermittent Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Changes in thymus weight

Blood: Changes in platelet count 		YACHDS 13,3753,1985
oral
human 		lowest published toxic dose: 0.6 mg/kg/14 day- intermittent Cardiac: Change in force of contraction

Cardiac: Change in rate

Vascular: Measurement of regional blood flow 		FATOAO 49,84,1986
oral
rat 		lowest published toxic dose: 22.75 mg/kg/26 week- continuous Cardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		FATOAO 48,76,1985
oral
rat 		lowest published toxic dose: 4,080 mg/kg/30 day- intermittent Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		FATOAO 48,76,1985
oral
rabbit 		lowest published toxic dose: 30 mg/kg/26 week- continuous Cardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		FATOAO 48,76,1985
oral
rabbit 		lowest published toxic dose: 4,080 mg/kg/30 day- intermittent Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP 		FATOAO 48,76,1985
skin
rat 		lowest published toxic dose: 1,500 mg/kg/30 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		YACHDS 9,1477,1981
skin
rat 		lowest published toxic dose: 25,480 mg/kg/26 week- intermittent Liver: Other changes

Blood: Pigmented or nucleated red blood cells

Blood: Changes in platelet count 		KSRNAM 18,2817,1984
skin
rabbit 		lowest published toxic dose: 4,900 mg/kg/5 week- intermittent Endocrine: Changes in thymus weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count 		KSRNAM 18,2794,1984
skin
woman 		lowest published toxic dose: 32 mg/kg/20 day- intermittent Skin: After topical application: Dermatitis, allergic CODEDG 45,299,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
NTIS** AD778-725
TOXICOLOGY REVIEW
ARPTDI 43,97,2003
TOXICOLOGY REVIEW
MUREAV 488,151,2001


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.2 ppm (2 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.02 ppm (0.2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.46 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.02 ppm (0.2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.9 mg/m3), short term exposure limit 0.3 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit - JAPAN short term exposure limit 0.05 ppm (0.46 mg/m3), Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.03 ppm (0.27 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 ppm (2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 ppm, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.03 ppm (0.3 mg/m3), KTV 0.1 ppm (0.9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.5 mg/m3), KZG- week 0.1 ppm (1 mg/m3),Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.2 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 ppm (2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 ppm (1.9 mg/m3), short term exposure limit 0.2 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGLYCERIN-air short term exposure limit 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50890;
Number of Industries 4;
Total Number of Facilities 413;
Number of Occupations 10;
Total Number of Employees Exposed 4,331
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50890;
Number of Industries 3;
Total Number of Facilities 384;
Number of Occupations 9;
Total Number of Employees Exposed 38,471;
Total Number of Female Employees Exposed 29,144


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a high exploxive and as a vasodilator
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitroglycerin, 2507
OSHA ANALYTICAL METHOD #43


REFERENCES:

CODEN
REFERENCE
AAPSP* AAPS pharmSci (electronic resource) (Alexandria, Va. : American Association of Pharmaceutical Scientists) V.1- 1999-
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BIPBU* Biological & pharmaceutical bulletin. (Pharmaceutical Society of Japan, 2-12-15, Shibuya, Shibuya-ku, Tokyo 150-0002, Japan) V.1- 1993-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MOCAE8 Molecular Carcinogenesis. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NAYXEW Nanjing Yixueyuan Xuebao. Journal of Nanjing Medical College. (Nanjing Yixueyuan, 140 Hanzhonglu, Nanjing, Peop. Rep. China) V.1- 1981(?)-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as a high exploxive and as a vasodilator

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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