The Registry of Toxic Effects of Chemical Substances

Nitric acid

RTECS #: QU5775000

CAS #: 7697-37-2

UPDATE: May 2004 MW: 63.02 MF: HNO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acide nitrique (French)
  2. Acido nitrico (Italian)
  3. Aqua fortis
  4. Azotic acid
  5. Azotowy kwas (Polish)
  1. Hydrogen nitrate
  2. Kyselina dusicne (Czech)
  3. Nitric acid (ACGIH:OSHA)
  4. Salpetersaure (German)
  5. Salpeterzuuroplossingen (Dutch)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 21,150 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ZHYGAM 29,667,1983
oral
rat 		lowest published toxic dose: 2,345 mg/kg (18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic ZHYGAM 29,667,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 300 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,45,1993
inhalation
cat 		lowest published lethal concentration: 500 mg/m3 N/R VCVN5* -,45,1993
inhalation
rat 		lethal concentration (50 percent kill): 260 mg/m3/30 minute N/R VCVN5* -,45,1993
inhalation
rat 		lethal concentration (50 percent kill): 130 mg/m3/4 hour N/R VCVN5* -,45,1993
oral
human 		lowest published lethal dose: 430 mg/kg N/R YAKUD5 22,651,1980
skin
rat 		lowest published toxic dose: 150 ml/kg Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,46,1993
unreported route
man 		lowest published lethal dose: 110 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,071 µg/m3/24 hour/84 day- continuous Behavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 38(3),6,1973
inhalation
rat 		lowest published toxic concentration: 50 µg/m3/4 hour/3 day- intermittent Lung, Thorax, or Respiration: Respiratory depression INHTE5 8,595,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm;short term exposure limit 4 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 4 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
ANAEA3 35,165,1975
TOXICOLOGY REVIEW
ARTODN 39,299,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (5 mg/m3) DTLVS* 3,181,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (5.2 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (5 mg/m3), short term exposure limit 5 ppm (13 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (5 mg/m3), VLE 5 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 2 ppm (5.2 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 2 ppm, short term exposure limit 2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 2 ppm (5 mg/m3), KTV 5 ppm (13 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 4 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 4 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITRIC ACID-air 10 hour time-weighted average 2 ppm;
short term exposure limit 4 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50742;
Number of Industries 197;
Total Number of Facilities 18,088;
Number of Occupations 101;
Total Number of Employees Exposed 132,401
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50742;
Number of Industries 201;
Total Number of Facilities 18,239;
Number of Occupations 120;
Total Number of Employees Exposed 297,627;
Total Number of Female Employees Exposed 76,316


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in chemicals, explosives, fertilizers, steel pickling, metal cleaning
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
OSHA ANALYTICAL METHOD #ID-127


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used in chemicals, explosives, fertilizers, steel pickling, metal cleaning

Top 50 chemical production: 16.08 billions lbs in 1992, 15.85 billions in 1991

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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