The Registry of Toxic Effects of Chemical Substances
Nicotine, tartrate (1:2) RTECS #: QT0350000
CAS #: 65-31-6
The Registry of Toxic Effects of Chemical Substances
Nicotine, tartrate (1:2) |
| UPDATE: May 2005 | MW: 462.46 | MF: C10H14N2•2C4H6O6 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
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N/R
|
N/R
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N/R
|
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
implant | rat
lowest published toxic dose: 712 µg/kg (12 day pregnant)
|
Reproductive: Effects on newborn: Biochemical and metabolic
|
TJADAB 29(3),28A,1984
|
implant | rat
lowest published toxic dose: 85,503 µg/kg (4-18 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system
|
BRBUDU 23,187,1989
|
implant | rat
lowest published toxic dose: 42 mg/kg (12-18 day pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | Reproductive: Effects on newborn: Biochemical and metabolic
JPETAB 248,786,1989
|
implant | rat
lowest published toxic dose: 126 mg/kg (1-21 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system
|
DBRRDB 68,233,1992
|
implant | rat
lowest published toxic dose: 34 mg/kg (4-20 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system
|
NETEEC 14,375,1992
|
implant | rat
lowest published toxic dose: 102 mg/kg (4-20 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Effects on newborn: Biochemical and metabolic
DBRRDB 102,117,1997
|
intraperitoneal | rat
lowest published toxic dose: 9,500 µg/kg (3-21 day pregnant)
|
Reproductive: Effects on newborn: Behavioral
|
PPTDD5 9(Suppl 1),39,1988
|
intravenous | monkey
lowest published toxic dose: 50 µg/kg (1 day prior to copulation)
|
Reproductive: Maternal effects: Ovaries, fallopian tubes
|
JRPFA4 31,91,1972
|
oral | rat
lowest published toxic dose: 210 mg/kg (10 day prior to copulation-10 day after birth)
|
Reproductive: Specific developmental abnormalities: Hepatobiliary system | Reproductive: Effects on newborn: Biochemical and metabolic
EXBME* 226,934,2001
|
subcutaneous | guinea pig
lowest published toxic dose: 68 mg/kg (1-68 day pregnant)
|
Reproductive: Effects on newborn: Behavioral
|
JGPSAY 120,49,1993
|
subcutaneous | mouse
lowest published toxic dose: 15,391 µg/kg (1-6 day pregnant)
|
Reproductive: Specific developmental abnormalities: Eye, ear
|
EPILAK 26,661,1985
|
subcutaneous | rat
lowest published toxic dose: 285 µg/kg (1 day male)
|
Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)
|
PSYPAG 10,44,1966
|
subcutaneous | rat
lowest published toxic dose: 75 mg/kg (1-5 day pregnant)
|
Reproductive: Effects on fertility: Other measures of fertility
|
BIREBV 20,294,1979
|
subcutaneous | rat
lowest published toxic dose: 90 mg/kg (1-21 day pregnant)
|
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | Reproductive: Effects on newborn: Sex ratio Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
PBBHAU 33,1,1989
|
subcutaneous | rat
lowest published toxic dose: 102 mg/kg (4-20 day pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | Reproductive: Effects on newborn: Biochemical and metabolic
JPETAB 251,894,1989
|
subcutaneous | rat
lowest published toxic dose: 36 mg/kg (4-21 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects
JPETAB 300,124,2002
|
subcutaneous | rat
lowest published toxic dose: 60 mg/kg (30 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Reproductive: Other effects on male Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
LIFSAK 71,3059,2002
|
subcutaneous | rat
lowest published toxic dose: 20 mg/kg (1-20 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Other developmental abnormalities
NETEEC 26,103,2004
|
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intracerebral | rat
lowest published toxic dose: 22.2 µg/kg
|
Behavioral: Change in psychophysiological tests
|
EJPHAZ 465,91,2003
|
intracerebral | rat
lowest published toxic dose: 32 µg/kg
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 168,271,2003
|
intraperitoneal | hamster
lethal dose (50 percent kill): 125 mg/kg
|
N/R
|
TXAPA9 22,324,1972
|
intraperitoneal | mouse
lethal dose (50 percent kill): 7 mg/kg
|
N/R
|
TXAPA9 177,77,2001
|
intraperitoneal | mouse
lowest published toxic dose: 1.2 mg/kg
|
Behavioral: Analgesia
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TXAPA9 177,77,2001
|
intraperitoneal | mouse
lowest published toxic dose: 3 mg/kg
|
Behavioral: Antianxiety
|
EJPHAZ 420,33,2001
|
intraperitoneal | rat
lethal dose (50 percent kill): 83 mg/kg
|
N/R
|
TXAPA9 22,324,1972
|
intraperitoneal | rat
lowest published toxic dose: 0.4 mg/kg
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 167,335,2003
|
intravenous | human
lowest published toxic dose: 20 ng/kg
|
Vascular: Other changes
|
CLPTAT 67,391,2000
|
intravenous | mouse
lethal dose (50 percent kill): 300 µg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Rigidity (includes catalepsy)
BJPCBM 35,161,1969
|
intravenous | mouse
lethal dose (50 percent kill): 2 mg/kg
|
N/R
|
HBPTO* 1,119,2001
|
intravenous | rat
lethal dose (50 percent kill): 600 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold
|
PLRCAT 5,341,1973
|
intravenous | rat
lowest published toxic dose: 0.2 mg/kg
|
Behavioral: Abuse
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JPETAB 303,664,2002
|
intravenous | rat
lowest published toxic dose: 0.8 mg/kg
|
Behavioral: Change in motor activity (specific assay)
|
JPETAB 303,664,2002
|
intravenous | rat
lowest published toxic dose: 12 mg/kg/24 hour
|
Brain and Coverings: Other degenerative changes | Biochemical: Metabolism (intermediary): Other proteins
LIFSAK 70,1543,2002
|
oral | mouse
lethal dose (50 percent kill): 65 mg/kg
|
N/R
|
PLRCAT 5,341,1973
|
oral | rat
lethal dose (50 percent kill): 65 mg/kg
|
N/R
|
PLRCAT 5,341,1973
|
parenteral | frog
lethal dose (50 percent kill): 337 mg/kg
|
N/R
|
ABMGAJ 28,681,1972
|
parenteral | rat
lethal dose (50 percent kill): 33,500 µg/kg
|
N/R
|
ABMGAJ 28,681,1972
|
subcutaneous | mouse
lethal dose (50 percent kill): 53 mg/kg
|
N/R
|
PLRCAT 5,341,1973
|
subcutaneous | mouse
lowest published toxic dose: 0.5 mg/kg
|
Behavioral: Change in motor activity (specific assay)
|
JOETD7 66,83,1999
|
subcutaneous | rat
lowest published toxic dose: 0.3 mg/kg
|
Behavioral: Change in psychophysiological tests
|
JPETAB 302,95,2002
|
subcutaneous | rat
lowest published toxic dose: 50 µg/kg
|
Eye: Other eye effects | Behavioral: Change in psychophysiological tests
EJPHAZ 465,83,2003
|
subcutaneous | rat
lowest published toxic dose: 0.45 mg/kg
|
Behavioral: Toxic psychosis
|
PSCHDL 164,309,2002
|
subcutaneous | rat
lowest published toxic dose: 0.1 mg/kg
|
Behavioral: Alteration of classical conditioning
|
PSCHDL 167,251,2003
|
subcutaneous | rat
lowest published toxic dose: 0.125 mg/kg
|
Behavioral: Change in motor activity (specific assay)
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PSCHDL 174,389,2004
|
subcutaneous | rat
lowest published toxic dose: 0.5 mg/kg
|
Behavioral: Antianxiety | Endocrine: Differential effect of sex or castration on observed toxicity
NEROEW 25,601,2001
|
subcutaneous | rat
lowest published toxic dose: 0.1 mg/kg
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 168,271,2003
|
subcutaneous | rat
lowest published toxic dose: 0.2 mg/kg
|
Behavioral: Alteration of classical conditioning | Behavioral: Change in psychophysiological tests
NEROEW 27,534,2002
|
unreported route | rat
lethal dose (50 percent kill): 30 mg/kg
|
N/R
|
SMWOAS 91,359,1961
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraperitoneal | mouse
lowest published toxic dose: 14 mg/kg/14 day- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
TOLED5 109,21,1999
|
intravenous | rat
lowest published toxic dose: 12.6 mg/kg/4 week- intermittent
|
Behavioral: Toxic psychosis | Behavioral: Change in motor activity (specific assay)
PSCHDL 164,309,2002
|
intravenous | rat
lowest published toxic dose: 0.6 mg/kg/2 week- intermittent
|
Behavioral: Abuse
|
PSCHDL 167,257,2003
|
oral | rat
lowest published toxic dose: 36 mg/kg/6 day- intermittent
|
Behavioral: Change in motor activity (specific assay)
|
NETEEC 22,695,2000
|
subcutaneous | mouse
lowest published toxic dose: 7.2 mg/kg/8 day- intermittent
|
Behavioral: Alteration of operant conditioning
|
JOETD7 66,83,1999
|
subcutaneous | rat
lowest published toxic dose: 5.25 mg/kg/15 day- intermittent
|
Behavioral: Change in motor activity (specific assay)
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EJPHAZ 417,117,2001
|
subcutaneous | rat
lowest published toxic dose: 1.8 mg/kg/4 day- intermittent
|
Behavioral: Toxic psychosis
|
PSCHDL 164,309,2002
|
subcutaneous | rat
lowest published toxic dose: 5.25 mg/kg/15 day- intermittent
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 173,98,2004
|
subcutaneous | rat
lowest published toxic dose: 63 mg/kg/7 day- continuous
|
Behavioral: Withdrawal | Behavioral: Abuse
PSCHDL 168,280,2003
|
subcutaneous | rat
lowest published toxic dose: 63 mg/kg/7 day- continuous
|
Behavioral: Withdrawal | Behavioral: Alteration of operant conditioning
NEROEW 25,55,2001
|
subcutaneous | rat
lowest published toxic dose: 140 mg/kg/28 day- continuous
|
Behavioral: Alteration of operant conditioning
|
EJPHAZ 486,175,2004
|
subcutaneous | rat
lowest published toxic dose: 2.8 mg/kg/1 week- intermittent
|
Behavioral: Alteration of classical conditioning
|
NEROEW 27,712,2002
|
subcutaneous | rat
lowest published toxic dose: 5.6 mg/kg/1 week- intermittent
|
Behavioral: Tolerance | Behavioral: Alteration of classical conditioning
NEROEW 27,712,2002
|
subcutaneous | rat
lowest published toxic dose: 2.4 mg/kg/3 day- intermittent
|
Behavioral: Change in psychophysiological tests
|
NEROEW 27,727,2002
|
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REVIEWS:
ORGANIZATION
|
STANDARD
|
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
N/R
|
N/R
|
N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
N/R
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REFERENCES:
CODEN
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REFERENCE
ABMGAJ
|
Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher
information, see BBIADT.
|
BIREBV
|
Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL
61820) V.1- 1969-
|
BJPCBM
|
British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21
2XS, UK) V.34- 1968-
|
BRBUDU
|
Brain Research Bulletin. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY
10523) V.1- 1976-
|
CLPTAT
|
Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and
Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
|
DBRRDB
|
Developmental Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam,
Netherlands) V.1- 1981-
|
EJPHAZ
|
European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam,
Netherlands) V.1- 1967-
|
EPILAK
|
Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3:
1909-55; Ser.4: V.1- 1959-
|
EXBME*
|
Experimental biology and medicine (Maywood, N.J.) (Society for Experimental Biology and
Medicine, Maywood, NJ : The Society) V. 226- 2001-
|
HBPTO*
|
Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
|
JGPSAY
|
Journal of General Psychology. (Journal Press, c/o Heldref Publications, 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1928-
|
JOETD7
|
Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick,
Ireland) V.1- 1979-
|
JPETAB
|
Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E.
Preston St., Baltimore, MD 21202) V.1- 1909/10-
|
JRPFA4
|
Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way,
Colchester, Essex CO2 8HP, UK) V.1- 1960-
|
LIFSAK
|
Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8,
1962-69; V.14- 1974-
|
NEROEW
|
Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010)
V.1- 1987-
|
NETEEC
|
Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford,
NY 10523) V.9- 1987-
|
PBBHAU
|
Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426,
Fayetteville, NY 13066) V.1- 1973-
|
PLRCAT
|
Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1969-
|
PPTDD5
|
Peptides. (Pergamon Press Inc., 660 White Plains Rd., Tarrytown, NY 10591-5153) V.1- 1980-
|
PSCHDL
|
Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way,
Secaucus, NJ 07094) V.47- 1976-
|
PSYPAG
|
Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information,
see PSCHDL.
|
SMWOAS
|
Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel,
Switzerland) V.50- 1920-
|
TJADAB
|
Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.1- 1968-
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
|
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