RTECS:QS9625000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Nicotine, sulfate (2:1)

RTECS #: QS9625000

CAS #: 65-30-5

UPDATE: August 2003 MW: 420.58 MF: C₂₀H₂₈N₄笧₄S

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

ENT 2,435

l - 1 - Methyl - 2 - (3 - pyridyl) - pyrrolidine sulfate

(S) - 3 - (1 - Methyl - 2 - pyrrolidinyl) pyridine sulfate (2:1)

l - 3 - (1 - Methyl - 2 - pyrrolidyl) pyridine sulfate

Nicotine sulfate

Nikotinsulfat (German)

Pyridine, 3 - (1 - methyl - 2 - pyrrolidinyl) - , (S) - , sulfate (2:1)

Pyrrolidine, 1 - methyl - 2 - (3 - pyridyl) - , sulfate

Sulfate de nicotine (French)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 1,670 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) BSTME2 3,31,1990/1991

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lethal concentration (50 percent kill): 22 mg/m³ N/R 85GMAT -,86,1982
intraperitoneal
cat lethal dose (50 percent kill): 20 mg/kg N/R 85GMAT -,86,1982
intraperitoneal
mouse lethal dose (50 percent kill): 10,200 痢/kg N/R JPPMAB 38,54,1986
intraperitoneal
rat lethal dose (90 percent kill): 29 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold NURIBL 23,43,1981
oral
wild bird lethal dose (50 percent kill): 32 mg/kg N/R TXAPA9 21,315,1972
oral
duck lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
mouse lethal dose (50 percent kill): 8,550 痢/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea HYSAAV 34(4-6),187,1969
oral
pigeon lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
quail lethal dose (50 percent kill): 316 mg/kg N/R AECTCV 12,355,1983
oral
rat lethal dose (50 percent kill): 50 mg/kg N/R ARSIM* 20,16,1966
skin
rat lethal dose (50 percent kill): 285 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement TXAPA9 2,88,1960
skin
rabbit lethal dose (50 percent kill): 50 mg/kg N/R 85GYAV -,141,1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 571 mg/kg/8 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 34(5),30,1969

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,194,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m³, JAN1993

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
BSTME2 Biological Structures and Morphogenesis. (Paris, Francs) V.1- 1988-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NURIBL Nutrition Reports International. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
Agricultural Chemical
Reproductive Effector

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