The Registry of Toxic Effects of Chemical Substances

Nickel (II) carbonate (1:1)

RTECS #: QR6200000

CAS #: 3333-67-3

UPDATE: May 2005 MW: 118.72 MF: CNiO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. C.I. 77779
  2. Nickel (2+) carbonate
  3. Carbonic acid, nickel salt (1:1)
  1. Nickel monocarbonate
  2. Nickelous carbonate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage intraperitoneal
rat 		10 mg/kg/3 hour CNREA8 42,3544,1982
other mutation test systems intraperitoneal
rat 		40 mg/kg CNREA8 44,3892,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 95 mg/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PAACA3 5,50,1964


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
guinea pig 		lowest published lethal dose: 32 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		JOHYAY 8,565,1908


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg(Ni)/m3 DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 11,75,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 49,257,1990
TOXICOLOGY REVIEW
ACLSCP 3,156,1973
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
85DHAX Ni,168,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Ni)/m3 DTLVS* 3,178,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 1 mg(Ni)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg(Ni)/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.1 mg(nI)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Ni)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg(Ni)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg(Ni)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL, INORGANIC-air Carcinogen;
10 hour time-weighted average 0.015 mg(Ni)/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81905;
Number of Industries 12;
Total Number of Facilities 349;
Number of Occupations 9;
Total Number of Employees Exposed 4,696
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81905;
Number of Industries 28;
Total Number of Facilities 864;
Number of Occupations 23;
Total Number of Employees Exposed 13,040;
Total Number of Female Employees Exposed 2,017


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of nickel catalysts
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1901-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-

Used in the production of nickel catalysts

RTECS Compound Description:
   Tumorigen
   Mutagen

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