The Registry of Toxic Effects of Chemical Substances

1 - Naphthylamine, N - phenyl -

RTECS #: QM4500000

CAS #: 90-30-2

UPDATE: August 2004 MW: 219.30 MF: C16H13N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Aceto PAN
  2. Additin 30
  3. Amoco 32
  4. 1 - Anilinonaphthalene
  5. Antigene PAN
  6. Antioxidant PAN
  7. C.I. 44050
  8. N - Fenyl - 1 - aminonaftalen (Czech)
  9. Fenyl - alpha - naftylamin (Czech)
  1. N - (1 - Naphthyl) aniline
  2. Neozone A
  3. PANA
  4. Phenylnaphthylamine
  5. Phenyl - alpha - naphthylamine
  6. alpha - Phenylnaphthylamine
  7. N - Phenyl - alpha - naphthylamine
  8. N - Phenyl - 1 - naphthylamine
  9. Vulkanox PAN


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 60 mg/L MUREAV 241,175,1990
dominant lethal test intraperitoneal
mouse 		830 mg/kg/5 day- intermittent NTIS** AD-A041-973
unscheduled DNA synthesis human lung 50 mg/L NTIS** AD-A041-973
mutation in microorganisms Salmonella typhimurium 10 µg/plate (+enzymatic activation step) SYSWAE 12,41,1979
mutation in microorganisms Salmonella typhimurium 500 nL/well (-enzymatic activation step) NTIS** AD-A041-973
morphological transform human other cell types 27,500 µg/L ITCSAF 17,719,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5,400 mg/kg/9 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors 		CNREA8 44,3098,1984
oral
mouse 		toxic dose : 17,280 mg/kg/9 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors 		CNREA8 44,3098,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 1,231 mg/kg N/R AMRL** TR-74-78,1974
oral
rat 		lethal dose (50 percent kill): 1,625 mg/kg N/R AMRL** TR-74-78,1974
skin
mouse 		lowest published toxic dose: 2.29 pph Immunological Including Allergic: Increased immune response TOXID9 72(Suppl 1),229,2003
skin
rabbit 		lowest published lethal dose: 8 gm/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0535072


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82955;
Number of Industries 45;
Total Number of Facilities 3,583;
Number of Occupations 46;
Total Number of Employees Exposed 39,803
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82955;
Number of Industries 127;
Total Number of Facilities 13,056;
Number of Occupations 88;
Total Number of Employees Exposed 184,126;
Total Number of Female Employees Exposed 16,560


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as rubber antioxidant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #96


REFERENCES:

CODEN
REFERENCE
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher information, see ICDBEO.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SYSWAE Shiyan Shengwu Xuebao. Journal of Experimental Biology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-77.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as rubber antioxidant

NIOSH PROFILE (AMINES, SECONDARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen

 Click Here for Additional Information about RTECS