The Registry of Toxic Effects of Chemical Substances

1 - Naphthylamine

RTECS #: QM1400000

CAS #: 134-32-7

UPDATE: July 2002 MW: 143.20 MF: C10H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Alfanaftilamina (Italian)
  2. alfa - Naftyloamina (Polish)
  3. 1 - Aminonaftalen (Czech)
  4. 1 - Aminonaphthalene
  5. C.I. Azoic Diazo Component 114
  6. Fast Garnet Base B
  7. Fast Garnet B Base
  8. alpha - Naftalamin (Czech)
  9. 1 - Naftilamina (Spanish)
  1. 1 - Naftylamin (Czech)
  2. alpha - Naftylamin (Czech)
  3. 1 - Naftylamine (Dutch)
  4. Naphthalidam
  5. Naphthalidine
  6. 1 - Naphthylamin (German)
  7. alpha - Naphthylamine (DOT:OSHA)
  8. RCRA waste number U167


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 60 mg/L/48 hour MUREAV 48,337,1977
cytogenetic analysis rat liver 25 mg/L PMRSDJ 1,570,1981
DNA adduct oral
dog 		60 µmol/kg EVHPAZ 49,125,1983
DNA damage Bacillus subtilis 2 mg/disc PMRSDJ 1,175,1981
DNA damage intraperitoneal
mouse 		150 mg/kg CRNGDP 2,265,1981
DNA damage oral
mouse 		400 mg/kg MUREAV 440,1,1999
DNA damage intraperitoneal
rat 		2,790 µmol/kg CRNGDP 2,1317,1981
DNA damage rat liver 3 mmol/L SinJF# 26OCT1982
DNA inhibition intraperitoneal
mouse 		20 gm/kg ARGEAR 51,605,1981
DNA repair Escherichia coli 25 mg/L JJIND8 62,873,1979
DNA repair Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,502,1981
unscheduled DNA synthesis hamster liver 50 µmol/L ENMUDM 6,1,1984
unscheduled DNA synthesis human fibroblast 10 mg/L PMRSDJ 1,528,1981
unscheduled DNA synthesis rat liver 700 µmol/L CNREA8 42,3010,1982
host-mediated assay mouse
Salmonella typhimurium 		167 mg/kg JJIND8 62,911,1979
host-mediated assay mouse
Escherichia coli 		33 mg/kg MUREAV 272,161,1992
mutation in microorganisms Bacillus subtilis 5 gm/L (-enzymatic activation step) MUREAV 42,19,1977
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+enzymatic activation step) PMRSDJ 1,261,1981
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) ENMUDM 6,497,1984
gene conversion and mitotic recombination Saccharomyes cerevisiae 50 ppm PMRSDJ 1,481,1981
mutation in mammalian somatic cells mouse lymphocyte 1,700 µg/L PMRSDJ 1,580,1981
morphological transform hamster embryo 100 mg/L AETODY 1,241,1980
morphological transform human other cell types 65 mg/L ITCSAF 17,719,1981
morphological transform mouse mammary gland 1 µg/L CNREA8 39,1784,1979
morphological transform oral
rat 		400 mg/kg CNREA8 40,1157,1980
other mutation test systems Escherichia coli 35 nmol/tube MUREAV 147,79,1985
phage inhibition capacity Escherichia coli 250 mg/L CNREA8 41,532,1981
sister chromatid exchange intraperitoneal
mouse 		38 mg/kg MUREAV 108,225,1983
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,468,1981
specific locus test hamster ovary 10 mg/L PMRSDJ 1,594,1981
sperm morphology intraperitoneal
mouse 		1,260 mg/kg/5 day- intermittent CMMUAO 5,257,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,300 mg/kg/13 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia 		CNREA8 28,535,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 96 mg/kg N/R PMRSDJ 1,682,1981
oral
mammal (species unspecified) 		lowest published lethal dose: 4 gm/kg N/R JIDHAN 13,87,1931
subcutaneous
rabbit 		lowest published lethal dose: 300 mg/kg Behavioral: Tremor

Behavioral: Muscle weakness 		XPHBAO 271,174,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 4,87,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 4,87,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,260,1987
TOXICOLOGY REVIEW
KHZHAZ 12(2),85,1976
TOXICOLOGY REVIEW
ADCSAJ 13,271,1970


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD skin-HUMAN CARCINOGEN, NO ASSIGNED time-weighted average DTLWS* 3,24,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1104 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1004,1987
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0 mg/m3, MAC(short term exposure limit) 0 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN Carcinogen, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-NAPHTHYLAMINE-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1004 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84304;
Number of Industries 2;
Total Number of Facilities 66;
Number of Occupations 2;
Total Number of Employees Exposed 610
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84304;
Number of Industries 1;
Total Number of Facilities 268;
Number of Occupations 5;
Total Number of Employees Exposed 2,132;
Total Number of Female Employees Exposed 1,796


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in dye production and for manufacturing herbicides and antioxidants
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthylamines, 5518
OSHA ANALYTICAL METHOD #93


REFERENCES:

CODEN
REFERENCE
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950-
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMMUAO Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher information, see ICDBEO.
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
KHZHAZ Khimiya i Zhizn. Chemistry and Life. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as an intermediate in dye production and for manufacturing herbicides and antioxidants

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen

 Click Here for Additional Information about RTECS