The Registry of Toxic Effects of Chemical Substances

1,4 - Naphthoquinone

RTECS #: QL7175000

CAS #: 130-15-4

UPDATE: November 2003 MW: 158.16 MF: C10H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,4 - Dihydro - 1,4 - diketonaphthalene
  2. 1,4 - Naftochinon (Czech)
  3. 1,4 - Naphthalenedione
  1. alpha - Naphthoquinone
  2. RCRA waste number U166
  3. USAF CY - 10


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 16 µg/plate (-enzymatic activation step) MUREAV 467,41,2000
micronucleus test human lymphocyte 100 µg/L MUREAV 393,23,1997


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 5 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes ENDOAO 57,466,1955


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 800 mg/kg/29 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		PIATA8 16,309,1940


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,500 µg/kg Tumorigenic: Active as anti-cancer agent JMCMAR 26,570,1983
intraperitoneal
rat 		lowest published lethal dose: 50 mg/kg N/R 85GMAT -,91,1982
intravenous
mouse 		lowest published lethal dose: 10 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		JPETAB 71,210,1941
oral
wild bird 		lethal dose (50 percent kill): 133 mg/kg N/R AECTCV 12,355,1983
oral
guinea pig 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VKMGA7 6,37,1966
oral
guinea pig 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,489,1994
oral
mouse 		lowest published lethal dose: 80 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		JPETAB 71,210,1941
oral
rat 		lethal dose (50 percent kill): 190 mg/kg Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VKMGA7 6,37,1966
oral
rat 		lethal dose (50 percent kill): 190 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,489,1994
subcutaneous
mouse 		lowest published lethal dose: 40 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		JPETAB 71,210,1941
subcutaneous
rat 		lethal dose (50 percent kill): 202 mg/kg N/R GTPZAB 16(5),52,1972
skin
rat 		lethal dose (50 percent kill): 202 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,489,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lowest published toxic dose: 72,800 µg/kg/26 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 30(11),12,1965
oral
rat 		lowest published toxic dose: 72,800 µg/kg/26 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 30(11),12,1965
oral
rat 		lowest published toxic dose: 6 gm/kg/30 day- intermittent Liver: Liver function tests impaired

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VKMGA7 6,37,1966
subcutaneous
rat 		lowest published toxic dose: 300 mg/kg/10 day- intermittent Endocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Changes in: Fe 		GTPZAB 16(5),52,1972
subcutaneous
rat 		lowest published toxic dose: 1,300 mg/kg/13 week- intermittent Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Changes in: Fe 		GTPZAB 16(5),52,1972
unreported route
rat 		lowest published toxic dose: 150 mg/kg/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,489,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for polymerization inhibitor in polyester resins, also for dyestuffs, intermediates
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PIATA8 Proceedings of the Imperial Academy of Tokyo. (Tokyo, Japan) V.1-21, 1912-45. For publisher information, see PJACAW.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VKMGA7 Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene. (Kiev, USSR) V.6, 1966. For publisher information, see GNAMAP.

Used for polymerization inhibitor in polyester resins, also for dyestuffs, intermediates

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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