The Registry of Toxic Effects of Chemical Substances

2 - Naphthol

RTECS #: QL2975000

CAS #: 135-19-3

UPDATE: February 2004 MW: 144.18 MF: C10H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Hydroxynaphthalene
  2. 2 - Naftol (Dutch)
  3. 2 - Naftolo (Italian)
  4. 2 - Naphthalenol
  5. 2 - Naphtol (French)
  6. Azogen developer A
  7. C.I. 37500
  8. C.I. Azoic Coupling Component 1
  9. C.I. Developer 5
  10. Developer A
  11. Developer AMS
  12. Developer BN
  1. Developer sodium
  2. Isonaphthol
  3. Naphthol
  4. Naphthol B
  5. beta - Hydroxynaphthalene
  6. beta - Monoxynaphthalene
  7. beta - Naftol (Dutch)
  8. beta - Naftolo (Italian)
  9. beta - Naphthol
  10. beta - Naphthyl alcohol
  11. beta - Naphthyl hydroxide
  12. beta - Naphtol (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg moderate BIOFX* 26-4/1973
skin
rabbit 		500 mg/24 hour mild BIOFX* 26-4/1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 5 gm/L MUREAV 42,19,1977
DNA repair Escherichia coli 2 mg/disc MUREAV 97,1,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 0.5 mg/m3 Behavioral: Headache

Kidney, Ureter, and Bladder: Hematuria

Nutritional and Gross Metabolic: Body temperature increase 		VCVGK* -,220,1994
inhalation
rat 		lethal concentration (50 percent kill): >770 mg/m3/1 hour Gastrointestinal: Changes in structure or function of salivary glands BIOFX* 26-4/1973
intraperitoneal
mouse 		lethal dose (50 percent kill): 97,500 mg/kg N/R EJMCA5 13,381,1978
oral
cat 		lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1289,1935
oral
cat 		lethal dose (50 percent kill): 90 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
guinea pig 		lethal dose (50 percent kill): 1,335 mg/kg N/R GISAAA 30(9),22,1965
oral
guinea pig 		lethal dose (50 percent kill): 1,300 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
mouse 		lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1289,1935
oral
mouse 		lethal dose (50 percent kill): 98 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
rat 		lethal dose (50 percent kill): 1,960 mg/kg N/R GTPPAF 8,145,1972
oral
rat 		lethal dose (50 percent kill): 1,980 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
rabbit 		lowest published lethal dose: 3,800 mg/kg N/R YKYUA6 31,1499,1980
oral
rabbit 		lethal dose (50 percent kill): 5,400 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
oral
rabbit 		lowest published lethal dose: 3,800 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
subcutaneous
guinea pig 		lowest published lethal dose: 2,670 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		AEPPAE 186,195,1937
subcutaneous
mouse 		lowest published lethal dose: 100 mg/kg N/R ZHINAV 64,113,1909
subcutaneous
mouse 		lowest published lethal dose: 100 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
subcutaneous
rat 		lowest published lethal dose: 2,940 mg/kg Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		AEPPAE 186,195,1937
subcutaneous
rat 		lowest published lethal dose: 2,490 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
subcutaneous
rabbit 		lowest published lethal dose: 3 gm/kg N/R HBAMAK 4,1289,1935
subcutaneous
rabbit 		lowest published lethal dose: 3,000 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		VCVGK* -,220,1994
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R BIOFX* 26-4/1973
unreported route
rabbit 		lowest published lethal dose: 3,800 mg/kg N/R YKYUA6 32,605,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,350 µg/m3/17 week- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		GISAAA 38(10),15,1973
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,221,1994
oral
guinea pig 		lowest published toxic dose: 8,008 mg/kg/26 week- intermittent Eye: Other eye effects

Kidney, Ureter, and Bladder: Other changes

Immunological Including Allergic: Decrease in cellular immune response 		VCVGK* -,221,1994
oral
guinea pig 		lowest published toxic dose: 800.8 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired

Blood: Pigmented or nucleated red blood cells 		VCVGK* -,221,1994
oral
rat 		lowest published toxic dose: 10,080 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BIOFX* 26-4/1973
oral
rat 		lowest published toxic dose: 107 mg/kg/35 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning 		GISAAA 30(9),22,1965
oral
rat 		lowest published toxic dose: 20,580 mg/kg/105 day- intermittent Blood: Other hemolysis with or without anemia VCVGK* -,221,1994
oral
rat 		lowest published toxic dose: 8,008 mg/kg/26 week- intermittent Eye: Other eye effects

Kidney, Ureter, and Bladder: Other changes

Immunological Including Allergic: Decrease in cellular immune response 		VCVGK* -,221,1994
oral
rat 		lowest published toxic dose: 800.8 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Liver function tests impaired

Blood: Pigmented or nucleated red blood cells 		VCVGK* -,221,1994
oral
rabbit 		lowest published toxic dose: 298 mg/kg/35 week- intermittent Liver: Liver function tests impaired GISAAA 30(9),22,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 47,75,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,266,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84296;
Number of Industries 18;
Total Number of Facilities 971;
Number of Occupations 18;
Total Number of Employees Exposed 6,346
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1957;
Number of Industries 1;
Total Number of Facilities 113;
Number of Occupations 1;
Total Number of Employees Exposed 453
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84296;
Number of Industries 11;
Total Number of Facilities 199;
Number of Occupations 26;
Total Number of Employees Exposed 10,985;
Total Number of Female Employees Exposed 590


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-
ZHINAV Zeitschrift fuer Hygiene und Infektionskrankheiten. (Berlin, Fed. Rep. Ger.) V.11-151, 1892-1965. For publisher information, see MMIYAO.

NIOSH PROFILE (LEATHER TANNING), SRI, 2/77

RTECS Compound Description:
   Drug
   Mutagen
   Primary Irritant

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