The Registry of Toxic Effects of Chemical Substances

Naphthalene, 2 - nitro -

RTECS #: QJ9760000

CAS #: 581-89-5

UPDATE: August 2004 MW: 173.18 MF: C10H7NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. beta - Nitronaphthalene
  1. 2 - Nitronaphthalene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Escherichia coli 5 mg/L JJIND8 62,873,1979
host-mediated assay mouse
Salmonella typhimurium 		125 mg/kg JJIND8 62,911,1979
mutation in microorganisms Salmonella typhimurium 3 µg/plate (+enzymatic activation step) MUREAV 216,211,1989
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) PNASA6 72,5135,1975
micronucleus test human lymphocyte 60 mg/L MUREAV 393,23,1997
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 pph JJIND8 62,901,1979
mutation in mammalian somatic cells human lymphocyte 80 mg/L MUREAV 393,23,1997
morphological transform hamster embryo 1 mg/L IJCNAW 19,642,1977
other mutation test systems Salmonella typhimurium 6 mg/L MUREAV 192,239,1987
specific locus test human other cell types 462 µmol/L/10 hour MUREAV 472,93,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 2,400 mg/kg/34 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		XPHCI* 17DEC1976
oral
monkey 		lowest published toxic dose: 340 gm/kg/5 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		GANNA2 61,79,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,300 mg/kg N/R JJIND8 62,911,1979
oral
rat 		lethal dose (50 percent kill): 4,400 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		34ZIAG -,428,1969
oral
rabbit 		lethal dose (50 percent kill): 2,650 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Methemoglobinemia- Carboxhemoglobinemia 		34ZIAG -,428,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 46,303,1989
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 46,303,1989
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 46,303,1989
TOXICOLOGY REVIEW
MUREAV 558,7,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.035 ppm (0.25 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-NITRONAPHTHALENE-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 16, 1976


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
XPHCI* U.S. Public Health Service, Current Intelligence Bulletin. (National Institute for Occupational Safety and Health, 5600 Fishers Lane, Rockville, MD 20857)

NIOSH PROFILE (NITROANAPHTHALENES), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen

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