The Registry of Toxic Effects of Chemical Substances

Naphthalene, decahydro -

RTECS #: QJ3150000

CAS #: 91-17-8

UPDATE: November 2004 MW: 138.28 MF: C10H18


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Naphthalane
  2. Bicyclo (4.4.O) decane
  3. Decalin
  4. De - kalin
  1. Dekalina (Polish)
  2. Naphthane
  3. Perhydronaphthalene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 50 ppm/24 hour/90 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors 		FAATDF 5,785,1985
inhalation
rat 		lowest published toxic concentration: 5 ppm/24 hour/90 day- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors 		FAATDF 5,785,1985
inhalation
rat 		lowest published toxic concentration: 50 ppm ppm/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		TOSCF2 72,223,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 319 ppm/8 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		NTIS** AD-A086-341
inhalation
human 		lowest published toxic concentration: 100 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		TGNCDL 2,40,1961
inhalation
mouse 		lowest published lethal concentration: 993 ppm/4 hour N/R NTIS** AD-A062-138
inhalation
rat 		lethal concentration (50 percent kill): 710 ppm/4 hour N/R ATDAEI 1,215,1992
oral
rat 		lethal dose (50 percent kill): 4,170 mg/kg N/R AMIHBC 4,119,1951
skin
rabbit 		lethal dose (50 percent kill): 5,900 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 5 ppm/24 hour/90 day- continuous Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Endocrine: Evidence of thyroid hyperfunction 		FAATDF 5,785,1985
inhalation
rat 		lowest published toxic concentration: 5 ppm/24 hour/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 5,785,1985
inhalation
rat 		lowest published toxic concentration: 125 ppm/22 hour/31 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		FCTOD7 25,53,1987
inhalation
rat 		lowest published toxic concentration: 50 ppm/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria 		TOSCF2 72,223,2003
inhalation
rat 		lowest published toxic concentration: 400 ppm/13 week- intermittent Liver: Changes in liver weight TOSCF2 72,223,2003
oral
rat 		lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		FCTOD7 25,345,1987
oral
rat 		lowest published toxic dose: 6 gm/kg/4 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		FCTOD7 25,345,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - HUNGARY time-weighted average 100 mg/m3, short term exposure limit 200 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84339;
Number of Industries 3;
Total Number of Facilities 46;
Number of Occupations 3;
Total Number of Employees Exposed 934
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84339;
Number of Industries 2;
Total Number of Facilities 81;
Number of Occupations 2;
Total Number of Employees Exposed 249;
Total Number of Female Employees Exposed 74


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8815;8EHQ-0892-8816
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used as solvent and chemical intermediate

RTECS Compound Description:
   Tumorigen
   Human Data

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