The Registry of Toxic Effects of Chemical Substances

Morpholine, 4 - ethyl -

RTECS #: QE4025000

CAS #: 100-74-3

UPDATE: November 2004 MW: 115.20 MF: C6H13NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. N - Ethylmorfolin (Czech)
  2. N - Ethylmorpholine
  3. 4 - Ethylmorpholine
  1. N - Ethylmorpholine (ACGIH:OSHA)
  2. NEM


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		453 mg open irritation test mild UCDS** 11/3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 6,667 µg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 18,000 mg/m3/2 hour N/R TPKVAL 15,116,1979
inhalation
rat 		lowest published lethal concentration: 2,000 ppm/4 hour N/R AMIHBC 10,61,1954
intravenous
mouse 		lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#04778
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 1,200 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 1,200 mg/kg N/R TPKVAL 15,116,1979
oral
rat 		lethal dose (50 percent kill): 1,780 mg/kg N/R DTLWS* 4,190,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 20 ppm (94 mg/m3) (skin) DTLVS* 3,113,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 20 ppm (94 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 20 ppm (94 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 20 ppm (94 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 20 ppm (94 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (23 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (24 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (23.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (47 mg/m3), short term exposure limit 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (23 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (23 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 23 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 5 ppm (25 mg/m3), KTV 10 ppm (50 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (70 mg/m3), KZG- week 40 ppm (140 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(Se)/m3, SEP2000
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (24 mg/m3), short term exposure limit 20 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-ETHYLMORPHOLINE-air 10 hour time-weighted average 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32840;
Number of Industries 3;
Total Number of Facilities 37;
Number of Occupations 3;
Total Number of Employees Exposed 967


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Mutagen
   Primary Irritant

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