The Registry of Toxic Effects of Chemical Substances

Molybdic acid, disodium salt

RTECS #: QA5075000

CAS #: 7631-95-0

UPDATE: May 2004 MW: 205.92 MF: MoO4•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Disodium molybdate
  2. Natriummolybdat (German)
  1. Sodium molybdate (VI)
  2. Sodium molybdate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
phage inhibition capacity Escherichia coli 16 mmol/L ENMUDM 6,59,1984
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 80 mmol/L MUTAEX 1,21,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
mouse 		lowest published toxic dose: 16,474 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >2,080 mg/m3/4 hour N/R PerDW# 18JUN1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 303 mg/kg N/R EQSSDX 1,1,1975
intraperitoneal
rat 		lethal dose (50 percent kill): 576 mg/kg N/R EQSSDX 1,1,1975
intravenous
cat 		lethal dose (50 percent kill): 917 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		AGSOA6 8,51,1967
oral
dog 		lethal dose (50 percent kill): 0.25 gm/kg Gastrointestinal: Contraction (isolated tissue)

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		VCVN5* -,316,1993
oral
guinea pig 		lethal dose (50 percent kill): 0.31 gm/kg Gastrointestinal: Contraction (isolated tissue)

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		VCVN5* -,316,1993
oral
rat 		lethal dose (50 percent kill): 4 gm/kg N/R PerDW# 18JUN1991
oral
rat 		lethal dose (50 percent kill): 0.25 gm/kg Gastrointestinal: Contraction (isolated tissue)

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		VCVN5* -,316,1993
subcutaneous
mouse 		lethal dose (50 percent kill): 570 mg/kg N/R AEPPAE 244,17,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
domestic animal 		lowest published toxic dose: 484 mg/kg/21 week- intermittent Blood: Other changes

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JANSAG 25,96,1966
oral
rat 		lowest published toxic dose: 18,200 mg/kg/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		PHTOEH 73(Suppl 2),87,1993
oral
rat 		lowest published toxic dose: 3,605 mg/kg/4 week- continuous Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		PSEBAA 91,638,1956
oral
rat 		lowest published toxic dose: 5.25 gm/kg/21 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		VCVN5* -,317,1989
oral
rabbit 		lowest published toxic dose: 3,343 mg/kg/26 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JOENAK 57,419,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg(Mo)/m3 DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
ADTEAS 5,51,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg(Mo)/m3 DTLVS* 3,173,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg(Mo)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg(Mo)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg(Mo)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg(Mo)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg(Mo)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 mg(Mo)/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg(Mo)/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg(Mo)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 mg(Mo)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg(Mo)/m3, VLE 10 mg(Mo)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 mg(Mo)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg(Mo)/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 10 mg(Mo)/m3 (total dust), JAN1999
Occupational Exposure Limit - SWEDEN NGV 5 mg(Mo)/m3 (resp. dust), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg(Mo)/m3, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 5 mg(Mo)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg(Mo)/m3, short term exposure limit 10 mg(Mo)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg(Mo)/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg(Mo)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81120;
Number of Industries 35;
Total Number of Facilities 1,540;
Number of Occupations 33;
Total Number of Employees Exposed 10,443
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81120;
Number of Industries 55;
Total Number of Facilities 2,082;
Number of Occupations 46;
Total Number of Employees Exposed 33,075;
Total Number of Female Employees Exposed 6,787


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as corrosion inhibitor, also used in fertilizers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AGSOA6 Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l'Agression. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1960-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
PerDW# Cyprus Copper Company. (9100 East Mineral Circle, P.O. Box 3299, Englewood, CO 80155)
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as corrosion inhibitor, also used in fertilizers

NIOSH PROFILE (MOLYBDENUM AND ITS COMPOUNDS), SRC, 12/79

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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