The Registry of Toxic Effects of Chemical Substances

Mineral oil

RTECS #: PY8030000

CAS #: 8012-95-1

UPDATE: November 2004 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Adepsine oil
  2. Alboline
  3. Bayol 55
  4. Bayol F
  5. Blandlube
  6. Crystol 325
  7. Crystosol
  8. Glymol
  9. Kondremul
  10. Liquid paraffin
  11. Neo - cultol
  1. Nujol
  2. Oil mist, mineral
  3. Oil mist, mineral (ACGIH:OSHA)
  4. Paraffin oil
  5. Paroleine
  6. Petrogalar
  7. Primol 355
  8. Primol D
  9. Saxol
  10. USP mineral oil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg moderate AJOPAA 29,1363,1946
skin
guinea pig 		100 mg/24 hour mild CTOIDG 94(8),41,1979
skin
rabbit 		100 mg/24 hour mild CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
man 		lowest published toxic concentration: 5 mg/m3/5 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		JJOMDZ 23,333,1981
intraperitoneal
mouse 		lowest published toxic dose: 14 gm/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		NATUAS 193,1086,1962
intraperitoneal
mouse 		toxic dose : 60 gm/kg/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors 		CNREA8 38,703,1978
intraperitoneal
mouse 		toxic dose : 60 gm/kg/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		IMMUAM 17,481,1969
intraperitoneal
mouse 		toxic dose : 50 gm/kg/9 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors

Immunological Including Allergic: Decreased immune response 		IJCNAW 6,422,1970
intraperitoneal
mouse 		toxic dose : 72 gm/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Tumors 		JOIMA3 92,747,1962
skin
mouse 		lowest published toxic dose: 332 gm/kg/20 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		ANYAA9 132,439,1965


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 22 gm/kg N/R ATXKA8 30,243,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 70 mg/m3/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Lung, Thorax, or Respiration: Other changes 		VCVPS* -,91,1998
skin
mouse 		lowest published toxic dose: 20,800 µL/kg/13 week- intermittent Liver: Changes in liver weight NTPTR* NIH-92-3340
skin
rat 		lowest published toxic dose: 5,200 µL/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NIH-92-3340


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 (O) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 (O);short term exposure limit 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 10 mg/m3 DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
PAASAH 54,171,1959


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,225,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 (particulate) DTLWS* 3,25,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 5 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 3 mg/m3, Group 1 Carcinogen, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - SWEDEN NGV 3 mg/m3, short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 10 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 10 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T1542;
Number of Industries 3;
Total Number of Facilities 22;
Number of Occupations 7;
Total Number of Employees Exposed 698
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1542;
Number of Industries 275;
Total Number of Facilities 49,328;
Number of Occupations 178;
Total Number of Employees Exposed 1,100,229;
Total Number of Female Employees Exposed 433,405


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in cosmetics, pharmaceutical bases, food and fiber production, as carriers and bases
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Oil mist, mineral, 5026
NTP 9th Report on Carcinogens, 2000:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMMUAM Immunology. (Blackwell Scientific Pub., 52 Beacon St., Boston, MA 02108) V.1- 1958-
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
JOIMA3 Journal of Immunology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1916-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PAASAH Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

Used in cosmetics, pharmaceutical bases, food and fiber production, as carriers and bases

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Human Data
   Primary Irritant

ALT CAS #: 39355-35-6
ALT CAS #: 79956-36-8
ALT CAS #: 83046-05-3
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