The Registry of Toxic Effects of Chemical Substances

Methyl sulfide

RTECS #: PV5075000

CAS #: 75-18-3

UPDATE: November 2003 MW: 62.14 MF: C2H6S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dimethyl monosulfide
  2. Dimethylsulfid (Czech)
  3. Dimethyl sulphide
  4. Exact - S
  5. Methane, thiobis - (9CI)
  6. Methyl monosulfide
  1. Methyl sulphide
  2. Methyl thioether
  3. Sulfure de methyle (French)
  4. 2 - Thiapropane
  5. Thiobis (methane)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,990,1986
skin
rabbit 		500 mg/24 hour mild FCTXAV 17,365,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 31,620 µg/m3 N/R GTPZAB 16(6),46,1972
inhalation
rat 		lethal concentration (50 percent kill): 40,250 ppm Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased 		LacHB# 09JUN1978
intraperitoneal
mouse 		lethal dose (50 percent kill): 8 gm/kg N/R IJRBA3 3,41,1961
oral
mouse 		lethal dose (50 percent kill): 3,700 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Antipsychotic

Nutritional and Gross Metabolic: Other changes 		FCTXAV 17,365,1979
oral
rat 		lethal dose (50 percent kill): 3,300 mg/kg Behavioral: General anesthetic

Behavioral: Change in motor activity (specific assay)

Behavioral: Irritability 		GISAAA 32(3),3,1967
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,365,1979
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,950 mg/kg N/R GTPZAB 16(6),46,1972
unreported route
mouse 		lethal dose (50 percent kill): 3,700 mg/kg N/R HBPTO* 1,827,2001
unreported route
rat 		lethal dose (50 percent kill): 3,300 mg/kg N/R HBPTO* 1,827,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 21 gm/kg/70 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases GISAAA 32(3),3,1967
oral
rat 		lowest published toxic dose: 24,500 mg/kg/14 week- intermittent Gastrointestinal: Other changes

Endocrine: Changes in thyroid weight 		FCTXAV 13,15,1975
oral
rabbit 		lowest published toxic dose: 3,412 mg/kg/33 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 32(3),3,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 1 ppm, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84745;
Number of Industries 5;
Total Number of Facilities 265;
Number of Occupations 20;
Total Number of Employees Exposed 3,920;
Total Number of Female Employees Exposed 200


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as presulfiding agent for variety of catalysts used by petroleum industry
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1959-
LacHB# Personal Communication from H.B. Lackey, Chemical Products Div., Crown Zellerbach, Camas, WA 98607, June 9, 1978

Used as presulfiding agent for variety of catalysts used by petroleum industry

RTECS Compound Description:
   Primary Irritant

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