The Registry of Toxic Effects of Chemical Substances

Methionine, DL -

RTECS #: PD0456000

CAS #: 59-51-8

UPDATE: June 2000 MW: 149.23 MF: C5H11NO2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Acimetion
  2. Banthionine
  3. Cynaron
  4. Dyprin
  5. Lobamine
  6. Meonine
  7. Mertionin
  8. Methilanin
  1. alpha - Amino - gamma - methylmercaptobutyric acid
  2. DL - 2 - Amino - 4 - (methylthio) butyric acid
  3. Lactet
  4. (+ - ) - Methionine
  5. DL - Methionine (9CI)
  6. Neston
  7. Racemethionine
  8. Metione


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 40 gm/kg (1-20 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		JRPFA4 33,109,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 1,500 mg/kg N/R YACHDS 5,2041,1977
intraperitoneal
rat 		lowest published lethal dose: 2 gm/kg N/R YACHDS 5,2041,1977
intravenous
mouse 		lowest published lethal dose: 300 mg/kg N/R YACHDS 5,2041,1977
intravenous
rat 		lethal dose : >400 mg/kg N/R YACHDS 5,2041,1977
oral
mouse 		lowest published lethal dose: 4 gm/kg N/R YACHDS 5,2041,1977
oral
rat 		lethal dose : >5 gm/kg N/R YACHDS 5,2041,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 36 gm/kg/30 day- continuous Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count 		JONUAI 79,101,1963
oral
rat 		lowest published toxic dose: 21 gm/kg/13 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		JONUAI 106,1714,1976
oral
rat 		lowest published toxic dose: 39 gm/kg/20 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight 		JONUAI 106,1714,1976
oral
turkey 		lowest published toxic dose: 33,600 mg/kg/4 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain POSCAL 57,699,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3271;
Number of Industries 5;
Total Number of Facilities 1,272;
Number of Occupations 27;
Total Number of Employees Exposed 16,781;
Total Number of Female Employees Exposed 4,397


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

FDA-over the counter drug

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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