The Registry of Toxic Effects of Chemical Substances

Methanol

RTECS #: PC1400000

CAS #: 67-56-1

UPDATE: February 2005 MW: 32.05 MF: CH4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alcool methylique (French)
  2. Alcool metilico (Italian)
  3. Bieleski's solution
  4. Carbinol
  5. Colonial Spirit
  6. Columbian Spirit
  7. Metanolo (Italian)
  8. Methanol (ACGIH)
  9. Methyl alcohol
  10. Methyl alcohol (DOT:OSHA)
  11. Methyl hydrate
  1. Methyl hydroxide
  2. Methylalkohol (German)
  3. Methylol
  4. Metylowy alkohol (Polish)
  5. Monohydroxymethane
  6. Pyroxylic Spirit
  7. RCRA waste number U154
  8. Wood Spirit
  9. Wood alcohol
  10. Wood naphtha


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		40 mg moderate UCDS** 3/24/1970
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,187,1986
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,187,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
grasshopper 		3,000 ppm IJEBA6 12,72,1974
cytogenetic analysis oral
mouse 		1 gm/kg ENMUDM 4,317,1982
cytogenetic analysis intraperitoneal
mouse 		75 mg/kg ENMUDM 5,381,1983
DNA damage oral
rat 		10 µmol/kg ENMUDM 4,317,1982
DNA inhibition human lymphocyte 300 mmol/L PNASA6 79,1171,1982
DNA repair Escherichia coli 20 mg/well MUREAV 133,161,1984
mutation in microorganisms mouse lymphocyte 7,900 mg/L (+enzymatic activation step) ENMUDM 7(Suppl 3),10,1985
mutation in microorganisms Saccharomyes cerevisiae 12 pph (-enzymatic activation step) GENRA8 37,173,1981
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sex chromosome loss and nondisjunction Aspergillus nidulans 56,000 ppm MUREAV 215,187,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,500 ppm/6 hour (7-9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 12,101,1992
inhalation
mouse 		lowest published toxic concentration: 5,000 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		TJADAB 47,175,1993
inhalation
mouse 		lowest published toxic concentration: 7,500 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		TJADAB 47,175,1993
inhalation
mouse 		lowest published toxic concentration: 2,000 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 47,175,1993
inhalation
mouse 		lowest published toxic concentration: 15,000 ppm (7-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FAATDF 21,508,1993
inhalation
rat 		lowest published toxic concentration: 20,000 ppm/7 hour (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system 		TJADAB 29(2),48A,1984
inhalation
rat 		lowest published toxic concentration: 20,000 ppm/7 hour (7-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Endocrine system 		FAATDF 5,727,1985
inhalation
rat 		lowest published toxic concentration: 10,000 ppm/7 hour (7-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 5,727,1985
inhalation
rat 		lowest published toxic concentration: 15,000 ppm/7 hour (7-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 11,118,1991
inhalation
rat 		lowest published toxic concentration: 2.6 mg/m3 (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,89,1994
intraperitoneal
mouse 		lowest published toxic dose: 5 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 130,417,1984
oral
mouse 		lowest published toxic dose: 40 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		TJADAB 47,175,1993
oral
mouse 		lowest published toxic dose: 4 gm/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 55,138,1997
oral
rat 		lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		ONGZAC 22(1),71,1991
oral
rat 		lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic 		ONGZAC 22(1),71,1991
oral
rat 		lowest published toxic dose: 20 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		TJADAB 49,399,1994
oral
rat 		lowest published toxic dose: 200 ppm/20 hour (78 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 14,75,1994
oral
rat 		lowest published toxic dose: 5,200 µL/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 11,503,1997
oral
rat 		lowest published toxic dose: 6,000 mg/kg (15-17 day pregnant) Reproductive: Effects on newborn: Behavioral VCVGK* -,89,1994
oral
rat 		lowest published toxic dose: 6,000 mg/kg (17-19 day pregnant) Reproductive: Effects on newborn: Behavioral VCVGK* -,89,1994
oral
rat 		lowest published toxic dose: 42 mL/kg (21 day after birth) Reproductive: Effects on newborn: Behavioral NETEEC 24,519,2002
oral
rat 		lowest published toxic dose: 82 mL/kg (21 day after birth) Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		NETEEC 24,519,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 44 gm/m3/6 hour Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands 		AGGHAR 5,1,1933
inhalation
cat 		lowest published lethal concentration: 4,400 mg/m3/6 hour N/R VCVGK* -,87,1984
inhalation
human 		lowest published toxic concentration: 86,000 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes 		AGGHAR 5,1,1933
inhalation
human 		lowest published toxic concentration: 300 ppm Eye: Visual field changes

Behavioral: Headache

Lung, Thorax, or Respiration: Other changes 		NPIRI* 1,74,1974
inhalation
monkey 		lowest published lethal concentration: 1,000 ppm N/R IECHAD 23,931,1931
inhalation
monkey 		lowest published lethal concentration: 1,300 mg/m3 N/R VCVGK* -,88,1984
inhalation
mouse 		lowest published lethal concentration: 50 gm/m3/2 hour N/R 85GMAT -,80,1982
inhalation
mouse 		lowest published toxic concentration: 120,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,87,1984
inhalation
mouse 		lowest published toxic concentration: 40,000 mg/m3/4 hour Behavioral: Alteration of classical conditioning VCVGK* -,87,1984
inhalation
rat 		lethal concentration (50 percent kill): 64,000 ppm/4 hour N/R NPIRI* 1,74,1974
inhalation
rat 		lowest published toxic concentration: 5,000 ppm/6 hour Endocrine: Change in LH TXCYAC 71,69,1992
inhalation
rabbit 		lethal concentration (50 percent kill): 81,000 mg/m3/14 hour N/R VCVGK* -,87,1984
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 3,556 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
hamster 		lethal dose (50 percent kill): 8,555 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
mouse 		lethal dose (50 percent kill): 10,765 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rat 		lethal dose (50 percent kill): 7,529 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rat 		lowest published toxic dose: 3,490 mg/kg Behavioral: Ataxia VCVGK* -,87,1984
intraperitoneal
rabbit 		lethal dose (50 percent kill): 1,826 mg/kg N/R EVHPAZ 61,321,1985
intravenous
cat 		lowest published lethal dose: 4,641 mg/kg N/R JPETAB 16,1,1920
intravenous
mouse 		lethal dose (50 percent kill): 4,710 mg/kg N/R EVHPAZ 61,321,1985
intravenous
rat 		lethal dose (50 percent kill): 2,131 mg/kg N/R EVHPAZ 61,321,1985
intravenous
rabbit 		lethal dose (50 percent kill): 8,907 mg/kg N/R EVHPAZ 61,321,1985
oral
dog 		lowest published lethal dose: 7,500 mg/kg N/R HBAMAK 4,1365,1935
oral
human 		lowest published lethal dose: 428 mg/kg Behavioral: Headache

Lung, Thorax, or Respiration: Other changes 		NPIRI* 1,74,1974
oral
human 		lowest published lethal dose: 143 mg/kg Eye: Optic nerve neuropathy

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		34ZIAG -,382,1969
oral
man 		lowest published toxic dose: 3,571 µL/kg Eye: Visual field changes

Lung, Thorax, or Respiration: Dyspnea

Blood: Other changes 		YAKUD5 35,2095,1993
oral
man 		lowest published toxic dose: 9,450 µL/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: General anesthetic

Nutritional and Gross Metabolic: Body temperature decrease 		AJEMEN 16,538,1998
oral
man 		lowest published lethal dose: 6,422 mg/kg Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		CMAJAX 128,14,1983
oral
man 		lowest published toxic dose: 3,429 mg/kg Eye: Visual field changes AMSVAZ 212,5,1982
oral
monkey 		lethal dose (50 percent kill): 7 gm/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Behavioral: Coma 		TXAPA9 3,202,1961
oral
monkey 		lowest published lethal dose: 5,000 mg/kg Eye: Mydriasis (pupilliary dilation)

Eye: Other eye effects 		VCVGK* -,88,1984
oral
mouse 		lethal dose (50 percent kill): 7,300 mg/kg N/R TXCYAC 25,271,1982
oral
mouse 		lowest published lethal dose: 420 mg/kg N/R VCVGK* -,87,1984
oral
rat 		lowest published toxic dose: 8 gm/kg Endocrine: Change in LH TOXID9 13,14,1993
oral
rat 		lethal dose (50 percent kill): 5,600 mg/kg N/R VCVGK* -,87,1984
oral
rat 		lowest published toxic dose: 3,500 mg/kg Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		FAATDF 28,264,1995
oral
rat 		lowest published toxic dose: 3 gm/kg Liver: Other changes TOXID9 72,315,2003
oral
rabbit 		lethal dose (50 percent kill): 14,200 mg/kg N/R FAONAU 48A,105,1970
oral
rabbit 		lowest published lethal dose: 7,500 mg/kg N/R VCVGK* -,87,1984
oral
woman 		lowest published toxic dose: 4 gm/kg Eye: Visual field changes

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		AMSVAZ 212,5,1982
oral
woman 		lowest published lethal dose: 10 mL/kg Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Gastrointestinal: Changes in structure or function of exocrine pancreas 		JTCTDW 38,297,2000
parenteral
frog 		lowest published lethal dose: 59 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity) 		AIPTAK 50,296,1935
subcutaneous
mouse 		lethal dose (50 percent kill): 9,800 mg/kg N/R VCVGK* -,87,1984
skin
monkey 		lowest published lethal dose: 393 mg/kg N/R IECHAD 23,931,1931
skin
rabbit 		lethal dose (50 percent kill): 15,800 mg/kg N/R NPIRI* 1,74,1974
unreported route
man 		lowest published lethal dose: 868 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
monkey 		lowest published toxic concentration: 6.5 mg/m3/6 hour/4 week- intermittent Eye: Conjunctiva irritation

Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight 		VCVGK* -,88,1994
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/12 hour/13 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Muscle contraction or spasticity 		GISAAA 24(10),7,1959
inhalation
rat 		lowest published toxic concentration: 2,610 ppm/6 hour/4 week- intermittent Endocrine: Changes in spleen weight TIHEEC 11,343,1995
inhalation
rat 		lowest published toxic concentration: 6.5 mg/m3/6 hour/4 week- intermittent Eye: Conjunctiva irritation VCVGK* -,88,1994
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/12 hour/120 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		VCVGK* -,89,1994
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/213 day- intermittent Eye: Other eye effects VCVGK* -,89,1994
intraperitoneal
rat 		lowest published toxic dose: 3,846 µg/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		TIHEEC 9,479,1993
intraperitoneal
rat 		lowest published toxic dose: 10 gm/kg/3 day- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other) NRTXDN 24,255,2003
oral
monkey 		lowest published toxic dose: 63,000 mg/kg/3 week- intermittent Liver: Other changes VCVGK* -,89,1994
oral
rat 		lowest published toxic dose: 2,885 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition IJTOFN 19,179,2000
oral
rat 		lowest published toxic dose: 12 gm/kg/8 week- intermittent Behavioral: Ataxia

Behavioral: Alteration of operant conditioning 		NETEEC 15,223,1993
oral
rat 		lowest published toxic dose: 7 mL/kg/7 day- intermittent Liver: Other changes

Biochemical: Effect on specific coenzyme: B vitamins including folate 		JDGRAX 10(1-2),25,1978
oral
rat 		lowest published toxic dose: 268.8 gm/kg/21 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 13,14,1993
oral
rat 		lowest published toxic dose: 625 mg/kg/200 day- continuous Liver: Other changes VCVGK* -,89,1994
skin
monkey 		lowest published toxic dose: 2 mL/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,88,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm (skin);short term exposure limit 250 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 250 ppm (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
REPTED 17,349,2003
TOXICOLOGY REVIEW
FNSCA6 2,67,1973
TOXICOLOGY REVIEW
JTEHD6 1,153,1975
TOXICOLOGY REVIEW
MJAUAJ 2,483,1978
TOXICOLOGY REVIEW
TOLED5 140-141,239,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (260 mg/m3) (skin) DTLVS* 3,155,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (260 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 200 ppm (260 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (260 mg/m3), short term exposure limit 250 ppm, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (260 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (262 mg/m3), short term exposure limit 250 ppm, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (260 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (260 mg/m3), short term exposure limit 250 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm, VLE 1000 ppm, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 50 mg/m3, short term exposure limit 100 mg/m3, Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (260 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 260 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (130 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (260 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 ppm, short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 200 ppm (250 mg/m3), KTV 250 ppm (350 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 200 ppm (260 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (260 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (255 mg/m3), short term exposure limit 250 ppm, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 250 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 250 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHANOL-air 10 hour time-weighted average 200 ppm (Sk);
short term exposure limit 250 ppm (Sk) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 45930;
Number of Industries 344;
Total Number of Facilities 78,840;
Number of Occupations 203;
Total Number of Employees Exposed 737,242
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 45930;
Number of Industries 373;
Total Number of Facilities 101,075;
Number of Occupations 225;
Total Number of Employees Exposed 1,620,617;
Total Number of Female Employees Exposed 388,352


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8989
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methanol, 2000
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
OSHA ANALYTICAL METHOD #91


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.52-224, 1919-88.
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CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR.
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1960-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IECHAD Industrial and Engineering Chemistry. (Washington, DC) V.15-62, 1923-70. For publisher information, see CHMTBL.
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
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Top 50 chemical production: 8.73 billions lbs in 1992, 8.71 billions in 1991

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SOLDER, MANUFACTURE AND USE), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 54841-71-3
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