The Registry of Toxic Effects of Chemical Substances
4,7 - Methanoindene, 3a,4,7,7a - tetrahydro - |
UPDATE: November 2004 | MW: 132.22 | MF: C10H12 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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skin | rabbit
9,300 µg/24 hour open irritation test
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severe
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AIHAAP 23,95,1962
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skin | rabbit
20 mg/24 hour
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moderate
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85JCAE -,50,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 22,400 mg/kg (multigeneration)
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Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TOXID9 15,166,1995
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | dog
lowest published lethal concentration: 773 ppm/1 hour
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N/R
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TXAPA9 20,552,1971
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inhalation | guinea pig
lethal concentration (50 percent kill): 770 ppm/4 hour
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N/R
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TXAPA9 20,552,1971
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inhalation | guinea pig
lethal concentration (50 percent kill): 2,100 mg/m3
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N/R
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VCVGH* -,106,1990
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inhalation | human
lowest published toxic concentration: 16 mg/m3
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Behavioral: Headache
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VCVGH* -,106,1990
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inhalation | mouse
lethal concentration (50 percent kill): 145 ppm/4 hour
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N/R
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TXAPA9 20,552,1971
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inhalation | mouse
lethal concentration (50 percent kill): 400 mg/m3/2 hour
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N/R
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VCVGH* -,106,1990
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inhalation | rat
lethal concentration (50 percent kill): 660 ppm/4 hour
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Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay)
NTIS** OTS0557739
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inhalation | rat
lethal concentration (50 percent kill): 610 mg/m3/4 hour
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N/R
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VCVGH* -,106,1990
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inhalation | rabbit
lethal concentration (50 percent kill): 771 ppm/4 hour
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N/R
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TXAPA9 20,552,1971
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inhalation | rabbit
lethal concentration (50 percent kill): 4,200 mg/m3
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N/R
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VCVGH* -,106,1990
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intraperitoneal | mammal (species unspecified)
lethal dose (50 percent kill): 960 mg/kg
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N/R
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NTIS** AD-A087-257
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intraperitoneal | mouse
lethal dose (50 percent kill): 200 mg/kg
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N/R
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NCIUS* PH43-64-886
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intraperitoneal | rat
lethal dose (50 percent kill): 200 mg/kg
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N/R
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NCIUS* PH43-64-886
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oral | domestic bird
lethal dose (50 percent kill): 1,010 mg/kg
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N/R
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NTIS** AD-A087-257
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oral | cattle
lethal dose (50 percent kill): 1,200 mg/kg
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Behavioral: Ataxia | Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** AD-A093-673
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oral | mouse
lethal dose (50 percent kill): 190 mg/kg
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N/R
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VCVGH* -,106,1990
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oral | rat
lethal dose (50 percent kill): 353 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Behavioral: Muscle weakness
TXAPA9 20,552,1971
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oral | rat
lethal dose (50 percent kill): 520 mg/kg
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Behavioral: Convulsions or effect on seizure threshold
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VCVGH* -,106,1990
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oral | rat
lethal dose (50 percent kill): 370 mg/kg
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N/R
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VCVGH* -,106,1990
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skin | rabbit
lethal dose (50 percent kill): 5,080 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Behavioral: Muscle weakness
TXAPA9 20,552,1971
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skin | rabbit
lethal dose (50 percent kill): 5.08 mL/kg
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N/R
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VCVGH* -,107,1990
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | mouse
lowest published toxic concentration: 72 ppm/7 hour/2 week- intermittent
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Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
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TXAPA9 20,552,1971
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inhalation | mouse
lowest published toxic concentration: 714 ppm/6 hour/11 day- continuous
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Lung, Thorax, or Respiration: Other changes | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0536197
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inhalation | rat
lowest published toxic concentration: 250 ppm/6 hour/2 week- intermittent
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Behavioral: Somnolence (general depressed activity) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
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inhalation | rat
lowest published toxic concentration: 35 ppm/7 hour/18 week- intermittent
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Liver: Changes in liver weight | Kidney, Ureter, and Bladder: Changes in bladder weight
TXAPA9 20,552,1971
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inhalation | rat
lowest published toxic concentration: 5 ppm/6 hour/13 week- intermittent
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Kidney, Ureter, and Bladder: Other changes in urine composition | Nutritional and Gross Metabolic: Changes in: Na Nutritional and Gross Metabolic: Changes in: P
TIHEEC 8,353,1992
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inhalation | rat
lowest published toxic concentration: 20 mg/m3/4 hour/26 week- intermittent
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Behavioral: Excitement | Vascular: BP elevation not characterized in autonomic section Kidney, Ureter, and Bladder: Proteinuria
GTPZAB 9(12),13,1965
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oral | rat
lowest published toxic dose: 182 mg/kg/26 week- intermittent
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Behavioral: Alteration of classical conditioning | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
GISAAA 51(2),77,1986
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oral | rat
lowest published toxic dose: 1,120 mg/kg/28 day- intermittent
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Kidney, Ureter, and Bladder: Changes in bladder weight | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ESKHA5 (108),71,1990
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 5 ppm
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DTLVS* TLV/BEI,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - AUSTRALIA
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time-weighted average 5 ppm (30 mg/m3), JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 0.5 ppm (3 mg/m3), JAN1999
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Occupational Exposure Limit - BELGIUM
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time-weighted average 5 ppm (27 mg/m3), JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 5 ppm (30 mg/m3), JAN1999
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Occupational Exposure Limit - FINLAND
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time-weighted average 5 ppm (30 mg/m3), short term exposure limit 10 ppm (54 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FRANCE
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VME 5 ppm (30 mg/m3), JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 0.5 ppm (3 mg/m3), JAN1999
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Occupational Exposure Limit - NORWAY
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time-weighted average 5 ppm (30 mg/m3), JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 3 mg/m3, 2003
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.5 ppm (3 mg/m3), KZG- week 1 ppm (6 mg/m3), JAN1999
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 5 ppm (27 mg/m3), SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | time-weighted average 5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
time-weighted average 5 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENE-air
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10 hour time-weighted average 5 ppm
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NIOSH* DHHS #95-121,1995
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 83439; | Number of Industries 24; Total Number of Facilities 2,292; Number of Occupations 38; Total Number of Employees Exposed 41,365
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 83439; |
Number of Industries 4; Total Number of Facilities 252; Number of Occupations 8; Total Number of Employees Exposed 6,248; Total Number of Female Employees Exposed 442 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used in production of pesticides, elastomers, resin systems and polymers
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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BJIMAG
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British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME
04046) V.1- 1944-
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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ESKHA5
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Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei
Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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GTPZAB
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Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
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NCIUS*
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Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by
The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117)
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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TIHEEC
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Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ
08540) V.1- 1985-
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TOXID9
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Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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TXAPA9
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Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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VCVGH*
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"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances:
Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
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