The Registry of Toxic Effects of Chemical Substances

Methane, triiodo -

RTECS #: PB7000000

CAS #: 75-47-8

UPDATE: November 2004 MW: 393.72 MF: CHI3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Carbon triiodide
  2. Dezinfekt V
  3. Iodoform
  4. Iodoform (ACGIH)
  1. Jodoform (Czech)
  2. NCI - C04568
  3. Triiodomethane
  4. Trijodmethane (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis hamster embryo 1 mg/L SHIGAZ 74,1385,1987
mutation in microorganisms Salmonella typhimurium 67 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
morphological transform hamster embryo 10 mg/L SHIGAZ 74,1385,1987
sister chromatid exchange hamster embryo 1 mg/L SHIGAZ 74,1385,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 165 ppm/7 hour Lung, Thorax, or Respiration: Respiratory stimulation JTEHD6 8,59,1981
inhalation
rat 		lethal concentration (50 percent kill): 183 ppm/7 hour N/R VCVGH* -,605,1990
oral
dog 		lowest published lethal dose: 10 gm/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		ZEPTAT 1,446,1905
oral
guinea pig 		lethal dose (50 percent kill): 487 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		ZDTUAB 27(5),9,1983
oral
mammal (species unspecified) 		lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1289,1935
oral
mouse 		lethal dose (50 percent kill): 470 mg/kg N/R GISAAA 52(11),74,1987
oral
rat 		lethal dose (50 percent kill): 355 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		ZDTUAB 27(5),9,1983
oral
rabbit 		lethal dose (50 percent kill): 450 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		ZDTUAB 27(5),9,1983
subcutaneous
mammal (species unspecified) 		lowest published lethal dose: 1,500 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
mouse 		lethal dose (50 percent kill): 630 mg/kg Behavioral: Antipsychotic

Vascular: Other changes

Lung, Thorax, or Respiration: Other changes 		TXAPA9 4,354,1962
subcutaneous
rabbit 		lowest published lethal dose: 500 mg/kg N/R ZEPTAT 1,446,1905
skin
rat 		lethal dose (50 percent kill): 1,184 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		ZDTUAB 27(5),9,1983
unreported route
frog 		lowest published lethal dose: 606 mg/kg N/R ZEPTAT 1,446,1905


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 875 mg/kg/35 day- intermittent Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		GISAAA 52(11),74,1987
oral
rat 		lowest published toxic dose: 2,166 mg/kg/61 day- intermittent Liver: Other changes ZDTUAB 27(5),9,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.6 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.6 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.6 ppm (10 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.6 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.2 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.6 ppm (10 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.6 ppm (9.8 mg/m3), short term exposure limit 1 ppm, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.6 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.6 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODOFORM-air 10 hour time-weighted average 0.6 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84474;
Number of Industries 2;
Total Number of Facilities 390;
Number of Occupations 5;
Total Number of Employees Exposed 1,882
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84474;
Number of Industries 4;
Total Number of Facilities 510;
Number of Occupations 12;
Total Number of Employees Exposed 22,584;
Total Number of Female Employees Exposed 20,381


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antiseptic, disinfectant on superfical wounds and in female reproductive tract
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,rat NCITR* NCI-TR-110,1978


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
ZDTUAB Zdravookhranenie Turkmenistana. Public Health of Turkmenistan. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1957-
ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie. (Berlin, Ger.) V.1-22, 1905-21. For publisher information, see REXMAS.

Used as an antiseptic, disinfectant on superfical wounds and in female reproductive tract

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

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