The Registry of Toxic Effects of Chemical Substances

Methane, trichlorofluoro -

RTECS #: PB6125000

CAS #: 75-69-4

UPDATE: November 2004 MW: 137.36 MF: CCl3F


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Algofrene type 1
  2. Arcton 9
  3. Electro - CF 11
  4. Eskimon 11
  5. F 11
  6. FC 11
  7. Fluorocarbon No. 11
  8. Fluorotrichloromethane
  9. Fluorotrichloromethane (OSHA)
  10. Fluorotrojchlorometan (Polish)
  11. Freon 11
  12. Freon 11A
  13. Freon 11B
  14. Freon HE
  15. Freon MF
  1. Frigen 11
  2. Genetron 11
  3. Halocarbon 11
  4. Isceon 131
  5. Isotron 11
  6. Ledon 11
  7. Methane, fluorotrichloro -
  8. Monofluorotrichloromethane
  9. NCI - C04637
  10. Refrigerant 11
  11. Trichlorofluoromethane (ACGIH:OSHA)
  12. Trichloromonofluoromethane
  13. Ucon flurocarbon 11
  14. Ucon refrigerant 11


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 16 pph/10 minute Cardiac: Change in rate AEHLAU 30,353,1975
inhalation
dog 		lethal concentration : 22 pph/10 minute Cardiac: Pulse rate decreased with fall in BP

Cardiac: Change in conduction velocity 		AEHLAU 30,353,1975
inhalation
dog 		lowest published toxic concentration: 868,500 mg/m3/10 minute Cardiac: Change in rate VCVGH* -,616,1990
inhalation
guinea pig 		lethal concentration (50 percent kill): 25 pph/30 minute N/R EJTXAZ 9,385,1976
inhalation
guinea pig 		lowest published toxic concentration: 145,000 mg/m3/2 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea 		VCVGH* -,616,1990
inhalation
human 		lowest published toxic concentration: 50,000 ppm/30 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Fibrosing alveolitis

Liver: Other changes 		EJTXAZ 9,385,1976
inhalation
mouse 		lethal concentration (50 percent kill): 10 pph/30 minute N/R EJTXAZ 9,385,1976
inhalation
mouse 		lowest published toxic concentration: 100 pph/10 minute Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP 		JAMAAP 214,81,1970
inhalation
mouse 		lowest published lethal concentration: 346,700 mg/m3/2 hour N/R VCVGH* -,616,1990
inhalation
rat 		lethal concentration (50 percent kill): 13 pph/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		HUTODJ 1,239,1982
inhalation
rat 		lowest published toxic concentration: 520,000 mg/m3/30 minute Behavioral: General anesthetic VCVGH* -,616,1990
inhalation
rat 		lowest published lethal concentration: 579,000 mg/m3/20 minute N/R VCVGH* -,616,1990
inhalation
rat 		lowest published lethal concentration: 868,000 mg/m3/4 minute N/R VCVGH* -,616,1990
inhalation
rabbit 		lethal concentration (50 percent kill): 25 pph/30 minute N/R EJTXAZ 9,385,1976
inhalation
rabbit 		lowest published toxic concentration: 289,500 mg/m3/2 minute Cardiac: Cardiac output

Vascular: BP lowering not characterized in autonomic section 		VCVGH* -,616,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,743 mg/kg Behavioral: Convulsions or effect on seizure threshold TOIZAG 18,363,1971
oral
rat 		lethal dose : >352 mg/kg N/R NTIS** OTS0520424


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 12,000 ppm/4 hour/10 day- intermittent Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		NTIS** OTS0571425


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 1000 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
FAZMAE 18,365,1974
TOXICOLOGY REVIEW
TXCYAC 3,311,1975
TOXICOLOGY REVIEW
NYSJAM 74,1939,1974
TOXICOLOGY REVIEW
AIHAAP 29,517,1968
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,312,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (5600 mg/m3) DTLVS* 3,118,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (5600 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (5600 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (5600 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (5600 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (5600 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1000 ppm (5600 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 1000 ppm (5620 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (2810 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (5600 mg/m3), short term exposure limit 1250 ppm (7000 mg/m3), JAN1993
Occupational Exposure Limit - GERMANY MAK 1000 ppm (5600 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 40 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit( continuous) 1000 ppm (5600 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 500 ppm (2800 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (5600 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 500 mg/m3, MAC( continuous) 5600 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1000 ppm (1000 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN NGV 500 ppm (3000 mg/m3), KTV 750 ppm (4500 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (5600 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (5600 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1000 ppm (5710 mg/m3), short term exposure limit 1250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 1000 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 1000 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUOROTRICHLOROMETHANE-air ceiling concentration 1000 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33565;
Number of Industries 304;
Total Number of Facilities 68,187;
Number of Occupations 173;
Total Number of Employees Exposed 785,337
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33565;
Number of Industries 142;
Total Number of Facilities 15,107;
Number of Occupations 119;
Total Number of Employees Exposed 267,742;
Total Number of Female Employees Exposed 95,886


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as blowing agent in production of polyurethane foams, and as a refrigerant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Fluorotrichloromethane, 1006
NIOSH Analytical Method, 1994: Trichlorofluoromethane, 1006
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse NCITR* NCI-TR-106,1978
NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat NCITR* NCI-TR-106,1978


REFERENCES:

CODEN
REFERENCE
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as blowing agent in production of polyurethane foams, and as a refrigerant

RTECS Compound Description:
   Tumorigen
   Human Data
   Hormone

ALT CAS #: 83589-40-6
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