The Registry of Toxic Effects of Chemical Substances

Methanesulfenyl chloride, trichloro -

RTECS #: PB0370000

CAS #: 594-42-3

UPDATE: November 2004 MW: 185.87 MF: CCl4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Clairsit
  2. Mercaptan methylique perchlore (French)
  3. Perchlormethylmerkaptan (Czech)
  4. Perchloromethyl mercaptan
  5. Perchloromethyl mercaptan (ACGIH:OSHA)
  1. RCRA waste number P118
  2. Trichloromethane sulfenyl chloride
  3. Trichloromethanesulphenyl chloride
  4. Trichloromethylsulfenyl chloride
  5. Trichloromethylsulphenyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 28ZPAK -,13,1972
skin
rabbit 		500 mg/24 hour severe 28ZPAK -,13,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 296 mg/m3/2 hour N/R 85GMAT -,97,1982
inhalation
rat 		lethal concentration (50 percent kill): 11 ppm/1 hour N/R TXAPA9 42,417,1977
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair 		NTIS** OTS0533569
intraperitoneal
rat 		lethal dose (50 percent kill): 25 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		NTIS** OTS0533569
intravenous
mouse 		lethal dose (50 percent kill): 56 mg/kg N/R CSLNX* NX#06768
oral
mouse 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair 		NTIS** OTS0533569
oral
rat 		lethal dose (50 percent kill): 82,600 µg/kg N/R 28ZPAK -,13,1972
skin
guinea pig 		lethal dose (50 percent kill): 500 µL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0533569
skin
rabbit 		lethal dose (50 percent kill): 1,410 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 1 ppm/8 hour/13 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting 		NTIS** OTS0558749
inhalation
guinea pig 		lowest published toxic concentration: 1 ppm/8 hour/13 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory stimulation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0558749
inhalation
rat 		lowest published toxic concentration: 1 ppm/8 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes NTIS** OTS0558749


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.8 mg/m3) DTLVS* 3,202,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.8 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.76 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.8 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.8 mg/m3), KZG- week 0.2 ppm, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.8 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PERCHLOROMETHYL MERCAPTAN-air 10 hour time-weighted average 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54800;
Number of Industries 6;
Total Number of Facilities 324;
Number of Occupations 17;
Total Number of Employees Exposed 9,112;
Total Number of Female Employees Exposed 1,677


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate for the synthesis of dyes and fungicides
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8978;8EHQ-0892-9092
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an intermediate for the synthesis of dyes and fungicides

RTECS Compound Description:
   Primary Irritant

 Click Here for Additional Information about RTECS