The Registry of Toxic Effects of Chemical Substances

Methane, tribromo -

RTECS #: PB5600000

CAS #: 75-25-2

UPDATE: February 2005 MW: 252.75 MF: CHBr3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Bromoform
  2. Bromoform (ACGIH:OSHA)
  3. Bromoforme (French)
  4. Bromoformio (Italian)
  5. Methenyl tribromide
  6. Methyl tribromide
  1. NCI - C55130
  2. RCRA waste number U225
  3. Tribrommethaan (Dutch)
  4. Tribrommethan (German)
  5. Tribromometan (Italian)
  6. Tribromomethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 110 µg/L ENMUDM 7,1,1985
cytogenetic analysis intraperitoneal
rat 		25,300 µg/kg MUREAV 242,111,1990
cytogenetic analysis oral
rat 		1,265 mg/kg/5 day- intermittent MUREAV 242,111,1990
DNA damage human lung 100 µmol/L/3 hour MUREAV 538,41,2003
mutation in microorganisms Salmonella typhimurium 666 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) NTPTR* NTP-TR-350,1989
micronucleus test intratracheal
mouse 		800 mg/kg/48 hour- intermittent NTPTR* NTP-TR-350,1989
micronucleus test multiple
non-mammalian species 		5 ppm MUREAV 292,83,1993
mutation in mammalian somatic cells mouse lymphocyte 200 mg/L NTPTR* NTP-TR-350,1989
morphological transform mouse fibroblast 0.5 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 290 µg/L ENMUDM 7,1,1985
sister chromatid exchange human lymphocyte 80 µmol/L ENVRAL 32,72,1983
sister chromatid exchange oral
mouse 		100 mg/kg/4 day- intermittent ENVRAL 32,72,1983
sister chromatid exchange intratracheal
mouse 		800 gm/L NTPTR* NTP-TR-350,1989
sister chromatid exchange rat leukocyte 20 µmol/L MUREAV 300,241,1993
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		3,000 ppm ENMUDM 7,677,1985
specific locus test oral
Drosophila melanogaster 		3,000 ppm NTPTR* NTP-TR-350,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5.6 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Maternal effects: Postpartum NTIS** #PB89169254
oral
mouse 		lowest published toxic dose: 47 gm/kg (15 week male/15 week prior to copulation-4 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB89169254
oral
mouse 		lowest published toxic dose: 200 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #PB89169254
oral
mouse 		lowest published toxic dose: 200 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB89169254


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 1,100 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CNREA8 37,2717,1977
oral
rat 		lowest published toxic dose: 10,400 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-350,1989
oral
rat 		lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB90-110149/AS
oral
rat 		lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB90-110149/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 12,100 mg/m3 N/R GTPZAB 18(4),55,1974
inhalation
mouse 		lethal concentration (50 percent kill): 12,100 mg/m3/2 hour Lung, Thorax, or Respiration: Other changes VCVGH* -,581,1990
inhalation
rat 		lowest published lethal concentration: 45 gm/m3/4 hour N/R 85GMAT -,28,1982
inhalation
rat 		lowest published toxic concentration: 3,900 mg/m3/2 hour Brain and Coverings: Changes in surface EEG VCVGH* -,581,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,274 mg/kg N/R VCVGH* -,572,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 414 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Behavioral: Antipsychotic 		TOLED5 15,251,1983
oral
human 		lowest published lethal dose: 143 mg/kg N/R 34ZIAG -,141,1969
oral
mouse 		lethal dose (50 percent kill): 1,072 mg/kg Lung, Thorax, or Respiration: Dyspnea NTPTR* NTP-TR-350,1989
oral
rat 		lethal dose (50 percent kill): 933 mg/kg Lung, Thorax, or Respiration: Dyspnea NTPTR* NTP-TR-350,1989
subcutaneous
mouse 		lethal dose (50 percent kill): 1,820 mg/kg N/R TXAPA9 4,354,1962
subcutaneous
rabbit 		lowest published lethal dose: 410 mg/kg N/R AEXPBL 28,201,1891


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		EVHPAZ 46,117,1982
oral
mouse 		lowest published toxic dose: 6,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-350,1989
oral
mouse 		lowest published toxic dose: 296 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVGH* -,581,1990
oral
mouse 		lowest published toxic dose: 21,000 mg/kg/15 week- intermittent Behavioral: Fluid intake NTIS** #PB89169254
oral
rat 		lowest published toxic dose: 6,230 mg/kg/4 week- continuous Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		JTSCDR 17,119,1992
oral
rat 		lowest published toxic dose: 13 gm/kg/13 week- intermittent Liver: Other changes NTPTR* NTP-TR-350,1989
oral
rat 		lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-350,1989
oral
rat 		lowest published toxic dose: 5,840 mg/kg/1 year- continuous Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 14,281,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 52,213,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1309,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,213,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1309,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1309,1999
TOXICOLOGY REVIEW
MUREAV 564,179,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (5 mg/m3) (skin) DTLVS* 3,28,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (5.2 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (5 mg/m3), short term exposure limit 1.5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (5600 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (5.3 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMOFORM-air 10 hour time-weighted average 0.5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13160;
Number of Industries 3;
Total Number of Facilities 43;
Number of Occupations 3;
Total Number of Employees Exposed 242
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13160;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 1,473;
Total Number of Female Employees Exposed 230


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180323/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate and solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Studies (gavage);clear evidence:rat
NCI Carcinogenesis Studies (gavage);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a chemical intermediate and solvent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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