The Registry of Toxic Effects of Chemical Substances

Methanethiol

RTECS #: PB4375000

CAS #: 74-93-1

UPDATE: November 2004 MW: 48.11 MF: CH4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Mercaptan methylique (French)
  2. Mercaptomethane
  3. Methaanthiol (Dutch)
  4. Methanethiol (OSHA)
  5. Methanthiol (German)
  6. Methvtiolo (Italian)
  7. Methyl mercaptan
  1. Methyl mercaptan (ACGIH:OSHA)
  2. Methylmercaptaan (Dutch)
  3. Metilmercaptano (Italian)
  4. RCRA waste number U153
  5. Thiomethanol
  6. Thiomethyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		99 pph/6 minute- continuous ENVRAL 7,286,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 6,530 µg/m3/2 hour N/R GTPZAB 16(6),46,1972
inhalation
rat 		lethal concentration (50 percent kill): 675 ppm Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased 		LacHB# 09JUN1978
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 60,670 µg/kg N/R GTPZAB 16(6),46,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 17 ppm/7 hour/13 week- intermittent Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		JTEHD6 8,71,1981
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/3 day- intermittent Behavioral: Excitement

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Nutritional and Gross Metabolic: Other changes 		NTIS** OTS0571484


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (1 mg/m3) DTLVS* 3,167,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 10 ppm (20 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (1 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (1 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 10 ppm (20 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (0.98 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (1 mg/m3), short term exposure limit 1.5 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.8 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 1 ppm, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (1 mg/m3), KZG- week 1 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 10 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (1 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHANETHIOL-air ceiling concentration 0.5 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 45850;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 45850;
Number of Industries 7;
Total Number of Facilities 147;
Number of Occupations 25;
Total Number of Employees Exposed 6,192;
Total Number of Female Employees Exposed 380


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110799/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Mercaptans, 2542
OSHA ANALYTICAL METHOD #26


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
LacHB# Personal Communication from H.B. Lackey, Chemical Products Div., Crown Zellerbach, Camas, WA 98607, June 9, 1978
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as intermediate

NIOSH PROFILE (MERCAPTANS), SRC, 10/77

RTECS Compound Description:
   Mutagen

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