The Registry of Toxic Effects of Chemical Substances
Methanethiol |
UPDATE: November 2004 | MW: 48.11 | MF: CH4S |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
sex chromosome loss and nondisjunction |
inhalation Drosophila melanogaster | 99 pph/6 minute- continuous | ENVRAL 7,286,1974 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lethal concentration (50 percent kill): 6,530 痢/m3/2 hour | N/R | GTPZAB 16(6),46,1972 |
inhalation rat | lethal concentration (50 percent kill): 675 ppm |
Lung, Thorax, or Respiration: Other changes Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Urine volume increased | LacHB# 09JUN1978 |
unreported route mammal (species unspecified) | lethal dose (50 percent kill): 60,670 痢/kg | N/R | GTPZAB 16(6),46,1972 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 17 ppm/7 hour/13 week- intermittent |
Endocrine: Changes in adrenal weight Endocrine: Changes in spleen weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | JTEHD6 8,71,1981 |
inhalation rat | lowest published toxic concentration: 100 ppm/6 hour/3 day- intermittent |
Behavioral: Excitement Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic: Other changes | NTIS** OTS0571484 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.5 ppm | DTLVS* TLV/BEI,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 0.5 ppm (1 mg/m3) | DTLVS* 3,167,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 10 ppm (20 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 0.5 ppm (1 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 0.5 ppm (1 mg/m3) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 10 ppm (20 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 0.5 ppm (1 mg/m3), JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 0.5 ppm (1 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 0.5 ppm (0.98 mg/m3), JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 0.5 ppm (1 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 0.5 ppm (1 mg/m3), short term exposure limit 1.5 ppm (3 mg/m3), JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 0.5 ppm (1 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 0.5 ppm (1 mg/m3), JAN1999 | |
Occupational Exposure Limit - HUNGARY | short term exposure limit 1 mg/m3, JAN1993 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 1 mg/m3, 2003 | |
Occupational Exposure Limit - NORWAY | time-weighted average 0.5 ppm (1 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 10 ppm (20 mg/m3), JAN1993 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 0.8 mg/m3, JAN1993 | |
Occupational Exposure Limit - SWEDEN | NGV 1 ppm, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 0.5 ppm (1 mg/m3), KZG- week 1 ppm (2 mg/m3), JAN1999 | |
Occupational Exposure Limit - THAILAND | time-weighted average 10 ppm (20 mg/m3), JAN1993 | |
Occupational Exposure Limit - TURKEY | time-weighted average 10 ppm (20 mg/m3), JAN1993 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 0.5 ppm (1 mg/m3), SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 0.5 ppm | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHANETHIOL-air | ceiling concentration 0.5 ppm/15 minute | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 45850; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 45850![]() Number of Industries 7; Total Number of Facilities 147; Number of Occupations 25; Total Number of Employees Exposed 6,192; Total Number of Female Employees Exposed 380 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110799/AS) | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as intermediate | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Mercaptans, 2542 | |
OSHA ANALYTICAL METHOD #26 |
REFERENCES: | |
CODEN |
REFERENCE |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
ENVRAL | Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
JTEHD6 | Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- |
LacHB# | Personal Communication from H.B. Lackey, Chemical Products Div., Crown Zellerbach, Camas, WA 98607, June 9, 1978 |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |