The Registry of Toxic Effects of Chemical Substances

Methanesulfonyl chloride

RTECS #: PB2790000

CAS #: 124-63-0

UPDATE: October 1997 MW: 114.55 MF: CH3ClO2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Chloromethyl sulfone
  2. Mesyl chloride
  3. Methanesulfonic acid chloride
  1. Methanesulphonyl chloride
  2. Methyl sulfochloride
  3. Methylsulfonyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe NTIS** OTS0571119
skin
rabbit 		500 mg severe NTIS** OTS0571119


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 32 µmol/L MUREAV 390,105,1997
mutation in microorganisms Salmonella typhimurium 250 µg/plate (+enzymatic activation step) MUREAV 320,165,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 620 mg/m3/6 hour Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands

Skin and Appendages: Other: Hair 		NTIS** OTS0571119
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		NTIS** OTS0571119
intraperitoneal
rat 		lowest published lethal dose: 5 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria 		NTIS** OTS0571119
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg Kidney, Ureter, and Bladder: Hematuria NTIS** OTS0571119
oral
rat 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria 		NTIS** OTS0571119
skin
guinea pig 		lethal dose (50 percent kill): 100 µL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0571119


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 500 mg/kg/2 week- intermittent Behavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of esophagus

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0571119


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5012;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 851;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen
   Primary Irritant

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