The Registry of Toxic Effects of Chemical Substances

Methane, nitro -

RTECS #: PA9800000

CAS #: 75-52-5

UPDATE: May 2005 MW: 61.05 MF: CH3NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Nitrocarbol
  2. Nitrometan (Polish)
  1. Nitromethane
  2. Nitromethane (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 750 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Eye: Tumors

Liver: Tumors 		NTPTR* NTP-TR-461,1997
inhalation
mouse 		lowest published toxic concentration: 46,350 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors 		NTIS** PB97-205967
inhalation
mouse 		lowest published toxic concentration: 23,175 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors 		NTIS** PB97-205967
inhalation
rat 		lowest published toxic concentration: 188 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTPTR* NTP-TR-461,1997
inhalation
rat 		lowest published toxic concentration: 9,656.25 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB97-205967


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 5,000 ppm/3 hour N/R JIHTAB 22,315,1940
inhalation
monkey 		lowest published lethal concentration: 1,000 ppm N/R INMEAF 16,441,1947
inhalation
mouse 		lowest published lethal concentration: 18 gm/m3/2 hour N/R 85GMAT -,93,1982
inhalation
rat 		lowest published lethal concentration: 12,750 mg/m3/1 hour N/R NTIS** OTS0516767
inhalation
rabbit 		lowest published lethal concentration: 5,000 ppm/6 hour N/R JIHTAB 22,315,1940
intraperitoneal
mouse 		lethal dose (50 percent kill): 110 mg/kg N/R KHFZAN 10(6),53,1976
intraperitoneal
rat 		lowest published lethal dose: 1,500 mg/kg N/R BSPLA9 (1),29,1973
intravenous
dog 		lowest published lethal dose: 800 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Lung, Thorax, or Respiration: Respiratory depression 		AMIHAB 11,102,1955
intravenous
rabbit 		lowest published lethal dose: 750 mg/kg N/R AMIHAB 11,102,1955
oral
dog 		lowest published lethal dose: 125 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Liver: Hepatitis (hepatocellular necrosis), zonal 		AMIHAB 11,102,1955
oral
mouse 		lethal dose (50 percent kill): 950 mg/kg N/R GISAAA 32(9),9,1967
oral
rat 		lethal dose (50 percent kill): 940 mg/kg N/R GISAAA 32(9),9,1967
oral
rabbit 		lowest published lethal dose: 750 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		JIHTAB 22,315,1940
skin
rabbit 		lethal dose : >2 gm/kg N/R NTIS** OTS0516767


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,500 ppm/6 hour/16 day- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Liver: Changes in liver weight 		NTPTR* NTP-TR-461,1997
inhalation
mouse 		lowest published toxic concentration: 188 ppm/6 hour/13 week- intermittent Olfaction: Deviated nasal septum

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NTP-TR-461,1997
inhalation
rat 		lowest published toxic concentration: 100 ppm/7 hour/2 year- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0530024
inhalation
rat 		lowest published toxic concentration: 375 ppm/6 hour/16 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Olfaction: Deviated nasal septum 		NTPTR* NTP-TR-461,1997
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/13 week- intermittent Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-461,1997
oral
rat 		lowest published toxic dose: 2,275 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 32(9),9,1967
oral
rat 		lowest published toxic dose: 10,500 µL/kg/15 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHAB 11,102,1955
oral
rabbit 		lowest published toxic dose: 2,275 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 32(9),9,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 77,564,2000
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (250 mg/m3) DTLVS* 3,187,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (250 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (250 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (250 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (250 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (250 mg/m3), short term exposure limit 150 ppm (375 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (250 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 50 mg/m3, 2003
Occupational Exposure Limit - SWEDEN NGV 20 ppm (50 mg/m3), KTV 50 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (250 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (254 mg/m3), short term exposure limit 150 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50910;
Number of Industries 19;
Total Number of Facilities 849;
Number of Occupations 22;
Total Number of Employees Exposed 14,084
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50910;
Number of Industries 108;
Total Number of Facilities 5,853;
Number of Occupations 92;
Total Number of Employees Exposed 134,803;
Total Number of Female Employees Exposed 46,338


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent and racing car fuel
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitromethane, 2527
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BSPLA9 Bulletin de la Societe de Pharmacie de Lille. (Societe de Pharmacie du Lille, 3, rue du Professeur Laguesse, 59045 Lille, Franch) V.1- 1945-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as solvent and racing car fuel

NIOSH PROFILE (NITROPARAFFINS), SRC, 11/81

RTECS Compound Description:
   Tumorigen

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