The Registry of Toxic Effects of Chemical Substances

Methane, dimethoxy -

RTECS #: PA8750000

CAS #: 109-87-5

UPDATE: November 2004 MW: 76.11 MF: C3H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Anesthenyl
  2. Bis (methoxy) methane
  3. Dimethoxymethane
  4. Dimethoxymethane (ACGIH:OSHA)
  5. Dimethyl formal
  6. Dioxapentane
  7. Formal
  1. Formaldehyde dimethylacetal
  2. Formaldehyde methyl ketal
  3. Methoxymethyl methyl ether
  4. Methylal
  5. Methylal (ACGIH:OSHA)
  6. Methylene dimethyl ether
  7. Metylal (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL moderate NTIS** OTS0536049


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 57 gm/m3/7 hour N/R 85JCAE -,259,1986
inhalation
mouse 		lethal concentration (50 percent kill): 57,000 mg/m3/7 minute N/R VCVGK* -,501,1994
inhalation
rat 		lethal concentration (50 percent kill): 15,000 ppm N/R NPIRI* 1,73,1974
intraperitoneal
rat 		lowest published lethal dose: 5 gm/kg N/R NTIS** OTS0524346
oral
rat 		lethal dose (50 percent kill): 6,653 mg/kg N/R GISAAA 11,16,1993
oral
rabbit 		lethal dose (50 percent kill): 5,708 mg/kg N/R PSEBAA 29,730,1932
skin
rabbit 		lethal dose : >16 mL/kg Eye: Iritis

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		NTIS** OTS0536049


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 35,100 mg/m3/7 hour/22 day- intermittent Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BJIMAG 8,279,1951
oral
rat 		lowest published toxic dose: 7,078 mg/kg/3 day- intermittent Behavioral: General anesthetic

Behavioral: Ataxia

Kidney, Ureter, and Bladder: Urine volume increased 		IJTOFN 19,179,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (3100 mg/m3) DTLVS* 3,154,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (3100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (3100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (3100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (3100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (3100 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1000 ppm (3100 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (3110 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1000 ppm (3100 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (3100 mg/m3), short term exposure limit 1250 ppm (3900 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (3100 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (3100 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3100 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (3100 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 3500 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (3100 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (3100 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1000 ppm (3160 mg/m3), short term exposure limit 1250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1000 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1000 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLAL-air 10 hour time-weighted average 1000 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26075;
Number of Industries 5;
Total Number of Facilities 122;
Number of Occupations 6;
Total Number of Employees Exposed 399
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26075;
Number of Industries 123;
Total Number of Facilities 9,104;
Number of Occupations 70;
Total Number of Employees Exposed 156,806;
Total Number of Female Employees Exposed 21,093


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methylal, 1611


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Primary Irritant

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