The Registry of Toxic Effects of Chemical Substances
Methane, dimethoxy - |
UPDATE: November 2004 | MW: 76.11 | MF: C3H8O2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 100 無 | moderate | NTIS** OTS0536049 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lethal concentration (50 percent kill): 57 gm/m3/7 hour | N/R | 85JCAE -,259,1986 |
inhalation mouse | lethal concentration (50 percent kill): 57,000 mg/m3/7 minute | N/R | VCVGK* -,501,1994 |
inhalation rat | lethal concentration (50 percent kill): 15,000 ppm | N/R | NPIRI* 1,73,1974 |
intraperitoneal rat | lowest published lethal dose: 5 gm/kg | N/R | NTIS** OTS0524346 |
oral rat | lethal dose (50 percent kill): 6,653 mg/kg | N/R | GISAAA 11,16,1993 |
oral rabbit | lethal dose (50 percent kill): 5,708 mg/kg | N/R | PSEBAA 29,730,1932 |
skin rabbit | lethal dose : >16 mL/kg |
Eye: Iritis Lung, Thorax, or Respiration: Other changes Liver: Other changes | NTIS** OTS0536049 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lowest published toxic concentration: 35,100 mg/m3/7 hour/22 day- intermittent |
Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BJIMAG 8,279,1951 |
oral rat | lowest published toxic dose: 7,078 mg/kg/3 day- intermittent |
Behavioral: General anesthetic Behavioral: Ataxia Kidney, Ureter, and Bladder: Urine volume increased | IJTOFN 19,179,2000 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 1000 ppm | DTLVS* TLV/BEI,2003 |
TOXICOLOGY REVIEW |
| MUREAV 539,77,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 1000 ppm (3100 mg/m3) | DTLVS* 3,154,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 1000 ppm (3100 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 1000 ppm (3100 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 1000 ppm (3100 mg/m3) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 1000 ppm (3100 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 1000 ppm (3100 mg/m3), JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 1000 ppm (3100 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 1000 ppm (3110 mg/m3), JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 1000 ppm (3100 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 1000 ppm (3100 mg/m3), short term exposure limit 1250 ppm (3900 mg/m3), JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 1000 ppm (3100 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 1000 ppm (3100 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 3100 mg/m3, 2003 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 1000 ppm (3100 mg/m3), JAN1993 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 3500 mg/m3, JAN1999 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 10 mg/m3, JAN1993 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 1000 ppm (3100 mg/m3), JAN1999 | |
Occupational Exposure Limit - TURKEY | time-weighted average 1000 ppm (3100 mg/m3), JAN1993 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 1000 ppm (3160 mg/m3), short term exposure limit 1250 ppm, SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 1000 ppm | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLAL-air | 10 hour time-weighted average 1000 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 26075; Number of Industries 5; Total Number of Facilities 122; Number of Occupations 6; Total Number of Employees Exposed 399 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 26075![]() Number of Industries 123; Total Number of Facilities 9,104; Number of Occupations 70; Total Number of Employees Exposed 156,806; Total Number of Female Employees Exposed 21,093 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Methylal, 1611 |
REFERENCES: | |
CODEN |
REFERENCE |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
BJIMAG | British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
IJTOFN | International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NPIRI* | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
PSEBAA | Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |